Lorazepam Impurity 12 CAS 837-58-1
| CAS No. | 837-58-1 |
| Molecular Formula | C13H9Cl2NO |
| Molecular Weight | 266.12 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Lorazepam Impurity 12 (CAS 837-58-1) is a certified pharmaceutical impurity reference standard with the molecular formula C13H9Cl2NO and a molecular weight of 266.12 g/mol.
Based on its molecular formula C13H9Cl2NO, Lorazepam Impurity 12 contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 266.12 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Lorazepam Impurity 12 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C13H9Cl2NO |
| Molecular Weight | 266.12 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1957 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
Related Lorazepam Standards
- Lorazepam EP Impurity A (CAS 2958-36-3)
- Lorazepam Impurity 11 (CAS CATO-C4X-104111)
- Lorazepam EP Impurity E (CAS 93955-15-8)
- Lorazepam Impurity 2 (CAS 773871-49-1)
- Lorazepam Impurity 21 (CAS CATO-C4X-104121)
- Lorazepam USP Related Compound D (CAS 54643-79-7)
- (S)-Lorazepam (CAS 110032-65-0)
- (R)-Lorazepam (CAS 91402-80-1)
Recommended Standards
- (2-amino-5-chlorophenyl)(3-chlorophenyl)methanone (CAS 5625-08-1)
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- Diclofenac EP Impurity B (CAS 22121-58-0)
- Pentafluorophenyl Fluorosulfonate (CAS 60129-86-4)
- Ruxolitinib Impurity 62 (CAS CATO-C4X-205862)
- Mirabegron Impurity 25 (CAS CATO-C4X-103225)
- Sumatriptan EP Impurity B (CAS 88919-51-1)
- m-Tolyl 8-methyl-2-phenylquinoline-4-carboxylate (CAS 355421-35-1)
- Ethyl 4,6-dimethoxypyrimidine-2-carboxylate (CAS 128276-49-3)
- Methyl (E)-3-hydroxy-2-phenylacrylate (CAS 19242-49-0)
- 3-(6-Methyl-5,6-dihydrothiazolo[2,3-c][1,2,4]triazol-3-yl)aniline (CAS 681837-49-0)
- 6-(Trifluoromethyl)imidazo[1,2-a]pyrimidine-3-carboxylic acid (CAS 944903-21-3)
- 6,7-Dibromoquinazolin-4(3H)-one (CAS 17519-00-5)
- Glucagon receptor antagonists-2 (CAS 202917-18-8)
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