Diclofenac EP Impurity B CAS 22121-58-0
| CAS No. | 22121-58-0 |
| Molecular Formula | C13H9Cl2NO |
| Molecular Weight | 266.12 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
As a process- or degradation-related impurity, Diclofenac EP Impurity B (CAS 22121-58-0, C13H9Cl2NO) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Based on its molecular formula C13H9Cl2NO, Diclofenac EP Impurity B contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 266.12 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
Physical & Chemical Properties
| Molecular Formula | C13H9Cl2NO |
| Molecular Weight | 266.12 g/mol |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1963 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
Related Diclofenac Standards
- Diclofenac potassium Impurity 7 (CAS CATO-C4X-10517)
- Diclofenac Impurity 18 (CAS 60805-30-3)
- Diclofenac Impurity 20 (CAS 60805-31-4)
- Diclofenac impurity 5 (CAS CATO-C4X-16145)
- Diclofenac EP Impurity C (CAS 27204-57-5)
- Diclofenac Impurity 11 (CAS 51550-51-7)
- Diclofenac sodium Impurity 7 (CAS 127792-34-1)
- Diclofenac Impurity 20 (CAS 15362-44-4)
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- 4-Bromo-1-fluoro-2-((2,2,2-trifluoroethoxy)methyl)benzene (CAS 1704067-06-0)
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