Roxatidine Impurity 61 CAS 83948-53-2
| CAS No. | 83948-53-2 |
| Molecular Formula | C8H16BrNO2 |
| Molecular Weight | 238.12 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The molecular framework of Roxatidine Impurity 61 (C8H16BrNO2) is characterized by an amide group, a carboxylic acid group, a hydroxyl group, an ether linkage, bromine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
As a process- or degradation-related impurity, Roxatidine Impurity 61 (CAS 83948-53-2, C8H16BrNO2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Roxatidine Impurity 61 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C8H16BrNO2 |
| Molecular Weight | 238.12 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 1.0 |
| CAS Registry Year (est.) | 1980 |
| Halogen Content | Br-containing |
| Nitrogen Atoms | 1 |
Related Roxatidine Standards
- Roxatidine Impurity 58 (CAS 115062-97-0)
- Roxatidine Impurity N1 (CAS 73278-98-5)
- Roxatidine Impurity 47 (CAS 4530-46-5)
- Roxatidine Impurity 48 (CAS 4530-45-4)
- Roxatidine Impurity 17 (CAS CATO-C4X-121317)
- Roxatidine Impurity 24 (CAS CATO-C4X-121324)
- Roxatidine Impurity 42 (CAS CATO-C4X-121342)
- Roxatidine Impurity 14 (CAS CATO-C4X-121314)
Recommended Standards
- Tert-butyl (S)-(1-bromopropan-2-yl)carbamate (CAS 263410-21-5)
- 2-(4,4-Dimethyl-3,4-dihydro-2H-pyran-6-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (CAS 1046812-00-3)
- Tert-butyl (R)-(1-bromopropan-2-yl)carbamate (CAS 263410-22-6)
- Bis(3,4-dimethylphenyl)(hydroxy)borane (CAS 1072946-23-6)
- Lysine Impurity 12 (CAS 44978-39-4)
- Nintedanib Impurity 91 (CAS CATO-C4X-181491)
- Difelikefalin Impurity 100 (CAS 1821319-30-5 (free base))
- 1-(Isoindoline-2-carbonyl)cyclopropanecarboxylic acid (CAS 1459289-81-6)
- methyl 2-[benzyl(2-methoxyethyl)amino]acetate (CAS 1803604-97-8)
- 2-(2,3-difluoro-4-methoxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (CAS 1809298-92-7)
- Methyl 3-bromo-5-(3,3-dimethylbut-1-yn-1-yl)thiophene-2-carboxylate (CAS 1355039-59-6)
- 4-Chloro-N-cyclopropyl-2-hydroxybenzamide (CAS 1019402-77-7)
- (S)-2-amino-3-(2,3,6-trifluorophenyl)propanoic acid (CAS 873429-60-8)
- Tau Peptide (74-102) (Exon 3/Insert 2 Domain) trifluoroacetate salt (CAS 1322695-34-0)
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