Esomeprazole Impurity 101 CAS 84006-10-0
| CAS No. | 84006-10-0 |
| Molecular Formula | C9H12ClNO |
| Molecular Weight | 185.65 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Owing to a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution, Esomeprazole Impurity 101 is typically off-white to pale yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 185.65 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
As a process- or degradation-related impurity, Esomeprazole Impurity 101 (CAS 84006-10-0, C9H12ClNO) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C9H12ClNO |
| Molecular Weight | 185.65 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1981 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
Related Esomeprazole Standards
- Esomeprazole Impurity 41 (CAS 1424857-95-3)
- Esomeprazole Impurity 86 (CAS 287118-45-0)
- Esomeprazole Impurity 109 (CAS 86604-79-7)
- Esomeprazole Impurity 48 (CAS CATO-C4X-111248)
- Esomeprazole Impurity 84 (CAS 149082-03-1)
- Esomeprazole Impurity 100 (CAS 142885-96-9)
- Esomeprazole Impurity 78 (CAS 49559-83-3)
- Esomeprazole Impurity 43 (CAS 149367-83-9)
Recommended Standards
- 920966-02-5 4-Chloro-1H-pyrrolo[2,3-b]pyridine-5-carbonitrile DTXSID50640137 (CAS 920966-02-5)
- 71406-66-1 4-Chloro-6-ethyl-N,N-dimethylpyrimidin-2-amine DTXSID60604644 (CAS 71406-66-1)
- Tirofiban Impurity 11 (CAS 2250243-43-5)
- p-Chlorophenylalaninol (CAS 35373-63-8)
- Luliconazole Impurity 8 (CAS CATO-C4X-28538)
- Trelagliptin Impurity 33 (CAS CATO-C4X-104633)
- Candesartan Impurity 7 (CAS CATO-C4X-15727)
- O-(3-Fluorophenethyl)hydroxylamine (CAS 863991-18-8)
- Parecoxib Impurity 23 (CAS 509074-26-4)
- 2-Chloro-N-(1-ethyl-3-methyl-1H-pyrazol-4-yl)acetamide (CAS 957514-01-1)
- Pioglitazone-d4 (CAS 1134163-29-3)
- Diclofenac Impurity 28 (CAS CATO-C4X-105128)
- 6-Amino-1-(pyridin-2-ylmethyl)pyrimidine-2,4(1H,3H)-dione (CAS 446266-75-7)
- Peptide 432 (CAS CATO-CPTD788432)
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