(4-Chloro-3-fluorophenyl)trimethylsilane CAS 845823-22-5
| CAS No. | 845823-22-5 |
| Molecular Formula | C9H12ClFSi |
| Molecular Weight | 202.73 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of (4-Chloro-3-fluorophenyl)trimethylsilane is closely related to fluorine/chlorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
(4-Chloro-3-fluorophenyl)trimethylsilane (CAS 845823-22-5) is a high-purity analytical reference standard with the molecular formula C9H12ClFSi and a molecular weight of 202.73 g/mol.
Structurally, (4-Chloro-3-fluorophenyl)trimethylsilane (C9H12ClFSi) contains fluorine/chlorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 3.0, corresponding to approximately 3 ring(s) or double-bond equivalent(s). With a molecular weight of 202.73 g/mol, it falls into the medium-molecular-weight range. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), (4-Chloro-3-fluorophenyl)trimethylsilane meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C9H12ClFSi |
| Molecular Weight | 202.73 g/mol |
| Purity | 97%+ |
| Storage | Store at room temperature, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO |
| Stability | May oxidize slowly on prolonged air exposure |
| Degree of Unsaturation (DBE) | 3.0 |
| UV Absorption | UV-absorbing |
| CAS Registry Year (est.) | 1987 |
| Halogen Content | F/Cl-containing |
Related Chloro Standards
- (4-Chloro-2-fluorophenyl)trimethylsilane (CAS 153357-87-0)
- 4-chloro-2,8-dimethyl-quinazoline (CAS 1429782-20-6)
- 4-chloro-2,8-dimethyl-1,7-naphthyridine (CAS 2205097-55-6)
- 4-chloro-6,7-dimethylquinazoline (CAS 31867-92-2)
- 66735-24-8 6-Chloro-2-methylquinolin-4-amine DTXSID00497037 (CAS 66735-24-8)
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- 948293-41-2 7-Chloro-8-methylquinolin-4-amine DTXSID20589049 (CAS 948293-41-2)
- 2-(3-Chloro-2-methylpropyl)-5-ethylthiophene (CAS 1479323-17-5)
Recommended Standards
- 1-(Trimethylsilyl)-3-chloro-4-fluorobenzene (CAS 845823-20-3)
- Benzene, 1-chloro-3-fluoro-2-(trimethylsilyl)- (CAS 133117-45-0)
- 1-(Trimethylsilyl)-3-chloro-5-fluorobenzene (CAS 845823-23-6)
- 3-(1-Chlorobutyl)-2,5-dimethylthiophene (CAS 1308106-91-3)
- 5-(Dibromomethyl)-2-(2-fluorophenyl)benzo[d]oxazole (CAS 1706454-01-4)
- 1-(3,5-Dichloro-4-fluorophenyl)thiourea (CAS 1263377-07-6)
- 2-Bromo-1-methoxy-3-methyl-5-(trifluoromethyl)benzene (CAS 2385955-13-3)
- 2-Amino-1-(2-((dimethylamino)methyl)pyrrolidin-1-yl)ethanone (CAS 1339693-09-2)
- LCZ-696 Impurity 34 (CAS 149690-12-0;752174-62-2（free base）)
- 5-Nitro-2-(3-phenylpropoxy)benzaldehyde (CAS 1156237-45-4)
- 4-Amino-1-ethylpiperidine-4-carboxylic acid (CAS 500756-05-8)
- Lurbinectedin (CAS 497871-47-3)
- 2-Amino-1,5-naphthalenedisulfonic acid (CAS 117-62-4)
- semaglutide (CAS 782487-28-9)
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