2-Chloro-1-(difluoromethyl)-4-fluorobenzene CAS 845866-83-3
| CAS No. | 845866-83-3 |
| Molecular Formula | C7H4ClF3 |
| Molecular Weight | 180.55 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 2-Chloro-1-(difluoromethyl)-4-fluorobenzene.
2-Chloro-1-(difluoromethyl)-4-fluorobenzene (CAS 845866-83-3) is a high-purity analytical reference standard with the molecular formula C7H4ClF3 and a molecular weight of 180.55 g/mol.
Based on its molecular formula C7H4ClF3, 2-Chloro-1-(difluoromethyl)-4-fluorobenzene contains fluorine/chlorine substitution, an aromatic ring system; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 180.55 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C7H4ClF3 |
| Molecular Weight | 180.55 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO |
| Stability | May oxidize slowly on prolonged air exposure |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1987 |
| Halogen Content | F/Cl-containing |
Related Chloro Standards
- 1-Chloro-3-(difluoromethyl)-5-fluorobenzene (CAS 1214333-10-4)
- 1-Chloro-3-(difluoromethyl)-2-fluorobenzene (CAS 1214333-71-7)
- 1-Chloro-4-(difluoromethyl)-2-fluoro-benzene (CAS 1214333-76-2)
- 4-Chloro-1-(difluoromethyl)-2-fluorobenzene (CAS 1214337-46-8)
- 1-Chloro-2-(difluoromethyl)-4-fluorobenzene (CAS 1214347-68-8)
- 2-Chloro-4-(difluoromethyl)-1-fluorobenzene (CAS 1214372-57-2)
- 2-Chloro-1-(difluoromethyl)-3-fluorobenzene (CAS 1214386-88-5)
- 4-Chloro-2-(difluoromethyl)-1-fluorobenzene (CAS 1228898-70-1)
Recommended Standards
- 2-(Chloromethyl)-1,3,5-trifluorobenzene (CAS 247564-62-1)
- 5-(chloromethyl)-1,2,3-trifluoro-Benzene (CAS 732306-27-3)
- 1-Chloro-2-(difluoromethyl)-3-fluorobenzene (CAS 63878-72-8)
- Dobutamine Impurity 26 (CAS 243139-71-1)
- 2,3,4,5,6-Pentafluorobenzyl acetate (CAS 2002-93-9)
- 4-(3-Chloro-4-fluorophenyl)-5-(4-methoxyphenyl)-4h-1,2,4-triazole-3-thiol (CAS 380349-22-4)
- Sodium 4-methylbenzoate (CAS 17264-54-9)
- 1-(furan-2-yl)-2,2-dimethylpropan-1-amine (CAS 331852-16-5)
- Losartan Impurity 50 (CAS CATO-C4X-168350)
- Methyl 9-bromononanoate (CAS 67878-15-3)
- 17a(H),21B(H)-30-Norhopane (CAS 53584-60-4)
- 3-Bromo-N,5-dimethylaniline (CAS 1369814-18-5)
- (S)-2-((3-((((benzyloxy)carbonyl)amino)methyl)oxetan-3-yl)amino)-4-(tert-butoxy)-4-oxobutanoic acid (CAS 2209840-31-1)
- Thymopoietin II Peptide Fragment (CAS 56795-64-3)
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