4-((3-(Trifluoromethyl)phenyl)sulfonyl)piperidine hydrochloride CAS 849035-98-9
| CAS No. | 849035-98-9 |
| Molecular Formula | C12H14F3NO2S |
| Molecular Weight | N/A |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
4-((3-(Trifluoromethyl)phenyl)sulfonyl)piperidine hydrochloride (CAS 849035-98-9), molecular formula C12H14F3NO2SHCl and molecular weight 329.76 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of 4-((3-(Trifluoromethyl)phenyl)sulfonyl)piperidine hydrochloride (C12H14F3NO2SHCl) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a sulfone group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
As a certified reference material (CRM), 4-((3-(Trifluoromethyl)phenyl)sulfonyl)piperidine hydrochloride meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C12H14F3NO2S HCl |
| Molecular Weight | 329.76 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1987 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 1 |
| Sulfur Atoms | 1 |
Related Trifluoromethyl Standards
- 3-(4-(Trifluoromethyl)phenyl)pyrrolidin-3-ol hydrochloride (CAS 1000198-74-2)
- 3-(4-(Trifluoromethyl)phenyl)pyrrolidine (CAS 1000198-76-4)
- (2-Methyl-4-(trifluoromethyl)thiazol-5-yl)methanol (CAS 1000339-72-9)
- methyl 3-((4-(trifluoromethyl)piperidin-1-yl)methyl)benzoate (CAS 1000339-86-5)
- methyl 4-(2-(4-(trifluoromethyl)piperidin-1-yl)ethoxy)benzoate (CAS 1000339-87-6)
- 2-(4-(trifluoromethyl)piperidin-1-yl)thiazole-5-carbaldehyde (CAS 1000339-88-7)
- 3-(2-(4-(trifluoromethyl)piperidin-1-yl)ethyl)benzaldehyde (CAS 1000339-89-8)
- 4-(2-(4-(trifluoromethyl)piperidin-1-yl)acetyl)-1H-pyrrole-2-carbaldehyde (CAS 1000339-90-1)
Recommended Standards
- 2-Chloro-6-((2-methylbut-3-yn-2-yl)amino)isonicotinic acid (CAS 1342005-20-2)
- 4-((4-(Tert-butyl)phenyl)sulfonyl)piperazin-2-one (CAS 851215-92-4)
- 17-Epimethandienone (CAS 33526-40-8)
- 4-Bromo-2-(((4-chlorophenyl)imino)methyl)-6-methoxyphenol (CAS 338417-07-5)
- (5-(2-Methoxyethyl)-1,2,4-oxadiazol-3-yl)methanamine hydrochloride (CAS 1177276-77-5)
- Dotinurad Impurity 230 (CAS CATO-C4X-2494230)
- Thiorphan Methoxyacetophenone-13C,d3 Derivative (CAS 1329837-24-2)
- Axitinib Impurity 38 (CAS 319472-78-1)
- 7-Chloro-5-phenyl-1H-benzo[e][1,4]diazepine-2,3-dione (CAS 20927-55-3)
- Semaglutide impurity 286 (CAS CATO-C4X-2226286)
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