3,5-Bis(methylsulfonyl)benzenesulfonyl chloride CAS 849035-99-0
| CAS No. | 849035-99-0 |
| Molecular Formula | C8H9ClO6S3 |
| Molecular Weight | 332.80 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
CATO supplies 3,5-Bis(methylsulfonyl)benzenesulfonyl chloride (CAS 849035-99-0), a certified reference material (molecular formula C8H9ClO6S3, MW 332.80 g/mol) for analytical method development and quality control.
Structurally, 3,5-Bis(methylsulfonyl)benzenesulfonyl chloride (C8H9ClO6S3) contains a sulfone group, a carboxylic acid group, a hydroxyl group, an ether linkage, chlorine substitution, an aromatic ring system. The molecule exhibits a degree of unsaturation (DBE) of 4.0, corresponding to approximately 4 ring(s) or double-bond equivalent(s). With a molecular weight of 332.80 g/mol, it falls into the moderately-high-molecular-weight range. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C8H9ClO6S3 |
| Molecular Weight | 332.80 g/mol |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), keep sealed and dry |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1987 |
| Halogen Content | Cl-containing |
| Sulfur Atoms | 3 |
Related Bis Standards
- N-(methylsulfonyl)-N-(2,4,5-trichlorophenyl)glycine (CAS 714260-75-0)
- 1-[(4-Methylsulfonyl)naphth-1-yl]piperidine-4-carboxamide (CAS 1000018-32-5)
- Benzyl 2-(methylsulfonyl)-5,7-dihydro-6H-pyrrolo[3,4-d]pyrimidine-6-carboxylate (CAS 2450291-49-1)
- Methyl 4-((2-(methylsulfonyl)phenyl)carbamoyl)benzoate (CAS 920393-57-3)
- N-(3-(6-(Methylsulfonyl)pyridazin-3-yl)phenyl)pentanamide (CAS 946327-49-7)
- 4-(4-(Methylsulfonyl)-6-(thiophen-2-yl)pyrimidin-2-yl)aniline (CAS 832075-88-4)
- 3-(Methylsulfonyl)phenyl 2H-chromene-3-carboxylate (CAS 1197476-20-2)
- N-(methylsulfonyl)-N-(4-phenoxyphenyl)alanine (CAS 1009535-60-7)
Recommended Standards
- 3-(2-Chlorophenyl)-5-methyl-N-(thiophen-2-ylmethyl)isoxazole-4-carboxamide (CAS 546062-75-3)
- 3-Chloro-N-(4,5,6,7-tetrahydrobenzo[c]isoxazol-3-yl)benzo[b]thiophene-2-carboxamide (CAS 946322-62-9)
- 2-Ethoxy-5-(pyrrolidine-1-carboxamido)benzenesulfonyl chloride (CAS 680618-12-6)
- 4-Chloro-2-(trimethylsilyl)phenyl trifluoromethanesulfonate (CAS 262373-16-0)
- ((2R,4R)-4-Aminotetrahydro-2H-pyran-2-yl)methanol (CAS 2770895-08-2)
- {2-[(4-methylphenyl)sulfanyl]pyridin-3-yl}methyl N-[3-(trifluoromethyl)phenyl]carbamate (CAS 338413-60-8)
- 1-(3-Phenylpropyl)azetidin-3-amine (CAS 1411710-59-2)
- Crizotinib Impurity 63 ·x p-Toluenesulfonic acid (CAS 2059996-30-2)
- 6-Bromo-2-methylpyrazolo[1,5-a]pyrimidine-3-carboxylic acid (CAS 96319-42-5)
- 5-Bromo-2-chloro-6-fluorobenzo[d]oxazole (CAS 1552012-28-8)
- 4-Hydroxycyclohexanecarboxylic acid (CAS 17419-81-7)
- Midazolam Impurity 1 (CAS 59468-90-5)
- 3-(4-Methoxybenzyl)phthalide 3-(p-Methoxybenzyl)phthalide 3-[(4-Methoxyphenyl)methyl]-1(3H)-isobenzofuranone 66374-23-0 (CAS 66374-23-0)
- Tirzepatide Impurity 16 (CAS CATO-C4X-324016)
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