Idarubicin impurity 16 CAS 85440-46-6
| CAS No. | 85440-46-6 |
| Molecular Formula | C26H27NO8 |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
Idarubicin impurity 16 (CAS 85440-46-6) is a certified pharmaceutical impurity reference standard with the molecular formula C26H27NO8HCl and a molecular weight of 517.96 g/mol.
The molecular framework of Idarubicin impurity 16 (C26H27NO8HCl) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
As a certified reference material (CRM), Idarubicin impurity 16 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C26H27NO8 HCl |
| Molecular Weight | 517.96 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at room temperature, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 13.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1981 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
Related Idarubicin Standards
- Idarubicin Hydrochloride Impurity 2 (CAS 1246818-54-1)
- Idarubicin Impurity 3 (CAS 16883-16-2)
- Idarubicin impurity 13 (CAS 220736-88-9)
- Idarubicin Hydrochloride (CAS 57852-57-0)
- Idarubicin (CAS 58957-92-9)
- Idarubicin Isomer (CAS 58957-93-0)
- Idarubicin Impurity 6 (CAS 60660-72-2)
- Idarubicin Impurity 1 (CAS 60660-75-5)
Recommended Standards
- Peptide Impurity 40 (CAS CATO-CPTD788840)
- Beclometasone Dipropionate Monohydrate EP Impurity V (CAS 205105-83-5)
- Leuprorelin EP Impurity G Acetate (CAS CATO-C4X-182220)
- Azetidin-3-yl methylcarbamate (CAS 1009409-62-4)
- 2-Amino-6-bromonaphthalene (CAS 7499-66-3)
- 2-Amino-3-(4-cyanophenyl)propanoic acid (CAS 22888-47-7)
- Pentadecylbenzene (CAS 2131-18-2)
- 3-Chloro-5-methoxy-4-propoxyphenol (CAS 1881295-38-0)
- 2-Isopropyl-2,5-diazabicyclo[2.2.1]heptane (CAS 444664-95-3)
- Peptide 46 (H-4054.0500) (CAS 192122-40-0)
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