Idarubicin Impurity 1 CAS 60660-75-5
| CAS No. | 60660-75-5 |
| Molecular Formula | C20H16O7 |
| Molecular Weight | 368.34 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Idarubicin Impurity 1.
Idarubicin Impurity 1 (CAS 60660-75-5) is a certified pharmaceutical impurity reference standard with the molecular formula C20H16O7 and a molecular weight of 368.34 g/mol.
Owing to a flavonoid core, a hydroxyl group, an ether linkage, Idarubicin Impurity 1 is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 368.34 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Idarubicin Impurity 1 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C20H16O7 |
| Molecular Weight | 368.34 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 13.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1974 |
Related Idarubicin Standards
Recommended Standards
- 68528-80-3 N-Hydroxysuccinimide suberic acid ester 2,5-Pyrrolidinedione, 1,1'-((1,8-dioxo-1,8-octanediyl)bis(oxy))bis- 1,1'-((1,8-Dioxo-1,8-octanediyl)bis(oxy))bis-2,5-pyrrolidinedione DSIS Nhs-SA (CAS 68528-80-3)
- Melphalan Impurity 32 (CAS CATO-C4X-198832)
- RO-4582640 (4-(8-Benzo[1,2,5]oxadiazol-5-yl-[1,7]naphthyridin-6-yl)-benzoic acid) (CAS 426268-06-6)
- Roxadustat Impurity 132 (CAS CATO-C4X-2213132)
- Allopurinol impurity 21 (CAS CATO-C4X-145821)
- Prilocaine Impurity 62 (CAS CATO-C4X-193462)
- Aripiprazole Impurity 31 (CAS 2748381-51-1)
- N-(2-Benzylbenzo[d]oxazol-5-yl)benzamide (CAS 590393-83-2)
- 1-Methyl-4-propoxybenzene (CAS 5349-18-8)
- Abrocitinib Impurity 35 (CAS CATO-C4X-288435)
- 5-((3-(Butylcarbamoyl)phenyl)amino)-5-oxopentanoic acid (CAS 940536-60-7)
- 3,6-Dinitro-9H-carbazole (CAS 3244-54-0)
- Methyl 2-chloro-5-isopropylbenzoate (CAS 2179038-25-4)
- Peptide Impurity 06 (CAS CATO-CPTD788806)
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