6-Chloroquinoline-4-carbonitrile CAS 854864-08-7
| CAS No. | 854864-08-7 |
| Molecular Formula | C10H5ClN2 |
| Molecular Weight | 188.61 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of 6-Chloroquinoline-4-carbonitrile is closely related to a nitrogen-containing heterocyclic scaffold, a nitrile group, chlorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
CATO supplies 6-Chloroquinoline-4-carbonitrile (CAS 854864-08-7), a certified reference material (molecular formula C10H5ClN2, MW 188.61 g/mol) for analytical method development and quality control.
The molecular framework of 6-Chloroquinoline-4-carbonitrile (C10H5ClN2) is characterized by a nitrogen-containing heterocyclic scaffold, a nitrile group, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C10H5ClN2 |
| Molecular Weight | 188.61 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, faint amine-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1987 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
Related Chloroquinoline Standards
- 2-Chloroquinoline-5-carbonitrile (CAS 1231761-06-0)
- 2-Chloroquinoline-8-carbonitrile (CAS 1231761-07-1)
- 8-Chloroquinoline-2-carbonitrile (CAS 1231761-08-2)
- 5-Chloroquinoline-4-carbonitrile (CAS 1231761-11-7)
- 8-Chloroquinoline-5-carbonitrile (CAS 1256463-59-8)
- 5-Chloroquinoline-7-carbonitrile (CAS 1256463-65-6)
- 4-Chloroquinoline-8-carbonitrile (CAS 132664-45-0)
- 7-Chloroquinoline-4-carbonitrile (CAS 13337-75-2)
Recommended Standards
- 6-Chloroquinoline-2-carbonitrile (CAS 52313-35-6)
- 7-Chloroquinoline-2-carbonitrile (CAS 65482-29-3)
- 6-Chloro-5-isopropylpyrimidine-2,4-diol (Impurity) (CAS 96796-80-4)
- 8-Chloroquinoline-4-carbonitrile (CAS 949535-26-6)
- 1,2-Distearoyl-sn-glycero-3-phospho-rac-(1-glycerol) Sodium Salt (CAS 200880-42-8)
- Ethyl 1-benzyl-1H-imidazole-4-carboxylate (CAS 76075-03-1)
- 2-(2-Isobutoxyphenyl)-6-oxo-1,6-dihydropyrimidine-5-carboxylic acid (CAS 63874-69-1)
- N,2-bis(4-chlorophenyl)-1-oxo-1,2-dihydroisoquinoline-4-carboxamide (CAS 477850-84-3)
- 4-Bromo-3-(methoxymethyl)-1-propyl-1H-pyrazole (CAS 1856041-72-9)
- 5,6-Difluoro-1H-indazole (CAS 944898-96-8)
- 2-(tert-Butyldimethylsiloxymethyl)phenol (CAS 96013-80-8)
- N-Acetyl-S-(1-carbamoyl-2-hydroxyethyl)cysteine (CAS 137698-09-0)
- 5,6-Dibromopyridine-2,3-diamine (CAS 1615736-65-6)
- Serpent Peptide (CAS 823202-99-9)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com