3,4-Dichloro-2,2-dimethylpropiophenone CAS 854891-91-1
| CAS No. | 854891-91-1 |
| Molecular Formula | C11H12Cl2O |
| Molecular Weight | 231.12 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
3,4-Dichloro-2,2-dimethylpropiophenone (CAS 854891-91-1), molecular formula C11H12Cl2O and molecular weight 231.12 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of 3,4-Dichloro-2,2-dimethylpropiophenone (C11H12Cl2O) is characterized by a hydroxyl group, an ether linkage, chlorine substitution, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C11H12Cl2O |
| Molecular Weight | 231.12 g/mol |
| Purity | 97%+ |
| Storage | Store at room temperature, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1987 |
| Halogen Content | Cl-containing |
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Recommended Standards
- 2,4-Dichloro-7,7-dimethyl-5,6,7,8-tetrahydroquinazoline (CAS 2768870-85-3)
- 3-Chloro-4-methylthiophene-2-sulfonyl chloride (CAS 2229137-51-1)
- 2,4-dichloro-6-fluoro-thieno[2,3-d]pyrimidine (CAS 2659313-20-7)
- 4,6-Dichloro-2-cyclohexylpyrimidine (CAS 94052-11-6)
- Methyl 2-amino-3-(5-bromo-2-methoxyphenyl)propanoate (CAS 845776-34-3)
- Morfamquat dichloride (CAS 4636-83-3)
- 2-[3-(Trifluoromethyl)phenyl]cyclopropane-1-carboxylic acid (CAS 721-22-2)
- 1-(3-(4-Methoxyphenyl)-1,2,4-oxadiazol-5-yl)-3-(methylthio)propan-1-amine (CAS 1154346-16-3)
- (1-Benzylindolin-5-yl)boronic acid (CAS 1106692-01-6)
- 3,5,6-Trichloro-2-pyridinol O-β-D-glucuronide (CAS 58997-12-9)
- [(1-Acetyl-piperidin-3-ylmethyl)-ethyl-amino]-acetic acid (CAS 1353944-46-3)
- (1-Methyl-5-phenoxy-3-(trifluoromethyl)-1H-pyrazol-4-yl)methanamine (CAS 956181-65-0)
- 5-Chloro-6-(m-tolylthio)pyrazine-2,3-dicarbonitrile (CAS 69148-96-5)
- Semaglutide impurity 64 (CAS CATO-C4X-222664)
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