Nintedanib Impurity 64 CAS 855860-75-2
| CAS No. | 855860-75-2 |
| Molecular Formula | C9H11ClN2O |
| Molecular Weight | 198.65 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Nintedanib Impurity 64 (CAS 855860-75-2) is a certified pharmaceutical impurity reference standard with the molecular formula C9H11ClN2O and a molecular weight of 198.65 g/mol.
Structurally, Nintedanib Impurity 64 (C9H11ClN2O) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 5.0, corresponding to approximately 5 ring(s) or double-bond equivalent(s). With a molecular weight of 198.65 g/mol, it falls into the medium-molecular-weight range. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
As a certified reference material (CRM), Nintedanib Impurity 64 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C9H11ClN2O |
| Molecular Weight | 198.65 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1987 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
Related Nintedanib Standards
- Nintedanib Impurity 109 (CAS CATO-C4X-1814109)
- Nintedanib Impurity 83 (CAS 14235-05-3)
- Nintedanib Impurity 29 (CAS 1373232-85-9)
- Nintedanib Impurity 41 (CAS 121-95-9)
- Nintedanib Impurity 33 (CAS 954239-49-7)
- Nintedanib Impurity 32 (CAS 380427-39-4)
- Nintedanib Impurity 72 (CAS 14192-26-8)
- Nintedanib Impurity 77 (CAS 1895918-24-7)
Recommended Standards
- 2-Amino-5-chloro-N,3-dimethylbenzamide (CAS 890707-28-5)
- Loxoprofen Impurity 19 (CAS 80530-55-8)
- Monuron (CAS 150-68-5)
- Naltrexone Impurity 13 (CAS 1201-90-7)
- Flucloxacillin impurity 13 (CAS CATO-C4X-164713)
- Loxoprofen Impurity 153 (CAS 1784924-28-2)
- Flunarizine Impurity 26 (CAS 144917-53-3)
- 2-(1-(2-Chloroacetyl)-3-oxopiperazin-2-yl)-N-(4-phenoxyphenyl)acetamide (CAS 1306738-30-6)
- Fmoc-p-nitro-D-Phe-OH (CAS 177966-63-1)
- 3-Benzyl-3-azabicyclo[3.2.1]octan-8-one (CAS 83507-33-9)
- Ethyl 4-(propylamino)piperidine-1-carboxylate (CAS 1020984-28-4)
- 2-Chloro-3-nitrobenzaldehyde (CAS 58755-57-0)
- 7,8-Dimethylchromane-3-carboxylic acid (CAS 1518904-21-6)
- Semaglutide Impurity 18 (CAS 1671100-14-3)
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