Nintedanib Impurity 33 CAS 954239-49-7
| CAS No. | 954239-49-7 |
| Molecular Formula | C11H11NO3 |
| Molecular Weight | 205.21 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Nintedanib Impurity 33 (CAS 954239-49-7) is a certified pharmaceutical impurity reference standard with the molecular formula C11H11NO3 and a molecular weight of 205.21 g/mol.
Nintedanib Impurity 33 (C11H11NO3) contains an amino-acid-derived structure, an amide group, a hydroxyl group, an ether linkage. It is notably hygroscopic, its high carbon-to-hydrogen ratio confers good lipid solubility, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
Physical & Chemical Properties
| Molecular Formula | C11H11NO3 |
| Molecular Weight | 205.21 g/mol |
| Appearance | Off-white to pale yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1987 |
| Nitrogen Atoms | 1 |
Related Nintedanib Standards
- Nintedanib Impurity 77 (CAS 1895918-24-7)
- Nintedanib Impurity 156 (CAS 1040320-04-4)
- Nintedanib Impurity 83 (CAS 14235-05-3)
- Nintedanib Impurity 165 (CAS 1351810-29-1)
- Nintedanib Impurity 161 (CAS 98953-48-1)
- Nintedanib Impurity 98 (CAS 1860012-61-8)
- Nintedanib Impurity 109 (CAS CATO-C4X-1814109)
- Nintedanib Impurity 64 (CAS 855860-75-2)
Recommended Standards
- Zonisamide Impurity 15 (CAS 23008-65-3)
- Cabozantinib Impurity 12 (CAS 145591-80-6)
- Itopride Impurity 27 (CAS CATO-C4X-137727)
- Tegoprazan Impurity 132 (CAS CATO-C4X-2297132)
- Leflunomide EP Impurity F (CAS 1403564-06-6)
- GST-HG171 Impurity 9 (CAS CATO-C4X-30609)
- Vortioxetine Impurity 116 (CAS 102439-46-3)
- 2-(Quinuclidin-3-yl)-2,3,3a,4,5,6-hexahydro-1h-benzo[de]isoquinolin-1-one hydrochloride (CAS 135729-74-7)
- Ethyl 6-hydroxy-5-isopropyl-3-methylpyrazine-2-carboxylate (CAS 816458-60-3)
- 4-Chloropyrido[2,3-d]pyridazin-5(6H)-one (CAS 1433204-20-6)
- Methyl 3,5-difluoro-4-hydroxybenzoate (CAS 170572-47-1)
- Cyclohexan-d11-ol (CAS 93131-17-0)
- 7-Amino-2-methyl-5-(methylthio)pyrazolo[1,5-a]pyrimidine-6-carbonitrile (CAS 174749-95-2)
- Neuropeptide SF (human) (CAS 192387-39-6)
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