Gefitinib D8 CAS 857091-32-8
| CAS No. | 857091-32-8 |
| Molecular Formula | - |
| Molecular Weight | 454.95 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The molecular framework of Gefitinib D8 (C22H16D8ClFN4O3) is characterized by deuterium isotope labeling, a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
Gefitinib D8 (CAS 857091-32-8), molecular formula C22H16D8ClFN4O3 and molecular weight 454.95 g/mol, is a CATO reference standard with documented purity and traceability.
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
As a certified reference material (CRM), Gefitinib D8 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C22H16D8ClFN4O3 |
| Molecular Weight | 454.95 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 16.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1987 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 4 |
Related Gefitinib Standards
Recommended Standards
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- Minesapride (CAS 1184662-54-1)
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- 2-Methyl-5-phenylpyrazolo[1,5-a]pyrimidine-7-carboxylic acid (CAS 932242-74-5)
- (3-Bromo-5-(thiazol-4-yl)phenyl)boronic acid (CAS 2225172-78-9)
- (E)-1,3-Dicyclopropylbut-2-en-1-one (CAS 37715-04-1)
- Trans-4-butylcyclohexanecarbaldehyde (CAS 80361-79-1)
- 3-Allyl-7-hydroxy-4-methyl-2H-chromen-2-one (CAS 26481-13-0)
- 2-(3-Phenyl-1,2,4-oxadiazol-5-yl)ethanamine hydrochloride (CAS 1185304-75-9)
- LY-487379, 98% (HPLC) (CAS 353231-17-1)
- Semaglutide impurity 23 (CAS CATO-C4X-222623)
Why CATO?
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