2-Bromo-4-chloro-6-fluorobenzonitrile CAS 858414-22-9
| CAS No. | 858414-22-9 |
| Molecular Formula | C7H2BrClFN |
| Molecular Weight | 234.45 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
2-Bromo-4-chloro-6-fluorobenzonitrile (CAS 858414-22-9) is a high-purity analytical reference standard with the molecular formula C7H2BrClFN and a molecular weight of 234.45 g/mol.
Owing to a nitrile group, fluorine/chlorine/bromine substitution, an aromatic ring system, 2-Bromo-4-chloro-6-fluorobenzonitrile is typically off-white to pale yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 234.45 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C7H2BrClFN |
| Molecular Weight | 234.45 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1987 |
| Halogen Content | F/Cl/Br-containing |
| Nitrogen Atoms | 1 |
Related Bromo Standards
- 5-Bromo-3-chloro-2-fluorobenzonitrile (CAS 1000577-76-3)
- 4-Bromo-2-chloro-5-fluorobenzonitrile (CAS 1126779-33-6)
- 3-Bromo-5-chloro-2-fluorobenzonitrile (CAS 1160574-15-1)
- 4-Bromo-3-chloro-2-fluorobenzonitrile (CAS 1160574-68-4)
- 4-Bromo-5-chloro-2-fluorobenzonitrile (CAS 1349716-15-9)
- 3-Bromo-4-chloro-5-fluorobenzonitrile (CAS 1357944-86-5)
- 3-Bromo-2-chloro-6-fluorobenzonitrile (CAS 1421620-33-8)
- 4-Bromo-2-chloro-3-fluorobenzonitrile (CAS 1427439-32-4)
Recommended Standards
- (4-Chloro-2-phenylpyrimidin-5-yl)boronic acid (CAS 2225169-73-1)
- 2-Bromo-5-chloro-4-fluorobenzonitrile (CAS 2055841-25-1)
- (3-Chloro-5-(pyrazin-2-yl)phenyl)boronic acid (CAS 2225177-93-3)
- 3-Bromo-2-chloro-4-fluorobenzonitrile (CAS 2091679-54-6)
- 5-Bromo-2-(difluoromethoxy)pyrimidine (CAS 1400581-05-6)
- {2-methyl-2-azabicyclo[2.2.2]octan-6-yl}methanol hydrochloride (CAS 1955554-74-1)
- 6-(4H-1,2,4-triazol-4-yl)picolinic acid (CAS 1060796-15-7)
- 2-(Cyclohexylmethyl)-6-hydroxybenzaldehyde (CAS 1243347-85-4)
- 4-(Methylthio)phenethyl acetate (CAS 1379324-13-6)
- 2-(4,5-Dibutyl-1H-1,2,3-triazol-1-yl)-4-methyl-6-phenylpyrimidine (CAS 861210-85-7)
- Econazole-d6 (CAS CATO-CCAD304748)
- 5-Amino-N-acetyltryptamine (CAS 393835-65-9)
- 3-(2-Chlorobenzyl)-6,8-diiodoquinazolin-4(3H)-one (CAS 302913-49-1)
- Semaglutide impurity 45 (CAS CATO-C4X-222645)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com