Prednisolone Impurity 42 CAS 85847-53-6
| CAS No. | 85847-53-6 |
| Molecular Formula | C22H29IO4 |
| Molecular Weight | 484.37 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a process- or degradation-related impurity, Prednisolone Impurity 42 (CAS 85847-53-6, C22H29IO4) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
The molecular framework of Prednisolone Impurity 42 (C22H29IO4) is characterized by a flavonoid core, a hydroxyl group, an ether linkage, iodine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C22H29IO4 |
| Molecular Weight | 484.37 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | >90% |
| Storage | Store at room temperature, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1981 |
| Halogen Content | I-containing |
Related Prednisolone Standards
- Prednisolone 21-Acetate 17-Valerate (CAS 72064-79-0)
- Prednisolone Impurity 44 (CAS 4224-31-1)
- Prednisolone 17-(Ethyl Carbonate) 21-Acetate (CAS 671225-23-3)
- Prednisolone Impurity 33 (CAS CATO-C4X-173733)
- Prednisolone Impurity 35 (CAS CATO-C4X-173735)
- Prednisolone Impurity 51 (CAS 1428883-48-0)
- Prednisolone Caproate (CAS 69164-69-8)
- Prednisolone Tebutate (CAS 7681-14-3)
Recommended Standards
- Clevidipine butyrate Impurity 22 (CAS CATO-C4X-101522)
- (βR)-6-Bromo-2-methoxy-α-1-naphthalenyl-β-phenyl-3-quinolineethanol (CAS 1298044-24-2)
- 4-(3,5-Bis(trifluoromethyl)benzyl)-6-(2-fluorophenyl)-4,5-dihydropyrido[3,2-f][1,4]oxazepin-3(2H)-one (CAS 877052-79-4)
- (3S,4R)-1-tert-Butyl 3-methyl 4-(6-Bromo-5-pival-amidopyridin-3-yl)pyrrolidine-1,3-dicarboxylate (CAS 1420780-27-3)
- Naproxen Impurity 41 (CAS CATO-C4X-170841)
- Vilanterol Impurity 30 (CAS 503070-62-0 (free base))
- Ozagrel Impurity 40 (CAS 883903-91-1)
- 4-Butoxy-2-(trifluoromethyl)aniline (CAS 121307-20-8)
- 3-Amino-6-ethyl-N-(4-methylbenzyl)-5,6,7,8-tetrahydrothieno[2,3-b]quinoline-2-carboxamide (CAS 445269-17-0)
- 2-oxabicyclo[2.2.2]octane-4-carboxylic acid (CAS 2168906-49-6)
- O-n-Butanoyl-2,3-O-diisopropylidene-α-D-mannofuranoside (CAS 177562-15-1)
- Bevantolol Impurity 4 (CAS CATO-C4X-24114)
- 3-(2-(4-Methylpiperazin-1-yl)ethoxy)aniline (CAS 890652-00-3)
- D-Asp9-Tirzepatide (CAS CATO-CPTD788923)
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