Prednisolone Impurity 44 CAS 4224-31-1
| CAS No. | 4224-31-1 |
| Molecular Formula | C23H29BrO6 |
| Molecular Weight | 481.38 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 481.38 g/mol gives Prednisolone Impurity 44 distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
Prednisolone Impurity 44 (CAS 4224-31-1) is a certified pharmaceutical impurity reference standard with the molecular formula C23H29BrO6 and a molecular weight of 481.38 g/mol.
Structurally, Prednisolone Impurity 44 (C23H29BrO6) contains a flavonoid core, a hydroxyl group, an ether linkage, bromine substitution. The molecule exhibits a degree of unsaturation (DBE) of 9.0, corresponding to approximately 9 ring(s) or double-bond equivalent(s). With a molecular weight of 481.38 g/mol, it falls into the moderately-high-molecular-weight range. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Prednisolone Impurity 44 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C23H29BrO6 |
| Molecular Weight | 481.38 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at room temperature, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1958 |
| Halogen Content | Br-containing |
Related Prednisolone Standards
- Prednisolone Impurity 42 (CAS 85847-53-6)
- Prednisolone 21-Acetate 17-Valerate (CAS 72064-79-0)
- Prednisolone 17-(Ethyl Carbonate) 21-Acetate (CAS 671225-23-3)
- Prednisolone Impurity 33 (CAS CATO-C4X-173733)
- Prednisolone Impurity 35 (CAS CATO-C4X-173735)
- Prednisolone Caproate (CAS 69164-69-8)
- Prednisolone Tebutate (CAS 7681-14-3)
- Prednisolone Impurity 64 (CAS 24808-87-5)
Recommended Standards
- Betamethasone Impurity 139 (CAS CATO-C4X-1437139)
- Nalmefene methiodide (CAS 136440-71-6)
- N-(5-Bromopyridin-3-yl)-4-methyl-N-tosylbenzenesulfonamide (CAS 1245644-89-6)
- (4-([1,1'-Biphenyl]-4-yl(9,9-dimethyl-9H-fluoren-2-yl)amino)phenyl)boronic acid (CAS 1265177-27-2)
- Mebeverine EP Impurity E (CAS 69788-75-6)
- Dequalinium Impurity 8 (CAS CATO-C4X-19368)
- Fluvoxamine Impurity 34 (CAS CATO-C4X-195134)
- tert-Butyl oxazol-4-ylcarbamate (CAS 1314931-66-2)
- 1-Methyl-5-(tributylstannyl)imidazole (CAS 147716-03-8)
- Methyl 4-(5-Oxazolyl)benzoate (CAS 179057-14-8)
- Timolol EP Impurity E (CAS 1026075-53-5)
- 4-(Methoxymethyl)-1-trityl-1H-imidazole (CAS 1956369-41-7)
- N-Allyl-4-(2-Chlorophenyl)Thiazol-2-Amine (CAS 21344-92-3)
- D-Val23-Tirzepatide (CAS CATO-CPTD788911)
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