Tofacitinib Impurity 125 HCl CAS 861020-12-4
| CAS No. | 861020-12-4 |
| Molecular Formula | C13H19N |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
CATO supplies Tofacitinib Impurity 125 HCl (CAS 861020-12-4), a pharmacopoeial impurity reference standard (molecular formula C13H19NHCl, MW 225.76 g/mol) used for the identification and quantification of trace impurities in APIs.
Owing to a nitrogen-containing heterocyclic scaffold, a nitrile group, chlorine substitution, Tofacitinib Impurity 125 HCl is typically off-white to pale yellow low-melting solid. Its solid-state physicochemical attributes — including a molecular weight of 225.76 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
CATO manufactures Tofacitinib Impurity 125 HCl under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C13H19N HCl |
| Molecular Weight | 225.76 g/mol |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1987 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
Related Tofacitinib Standards
- Tofacitinib Impurity 180 (CAS 100047-45-8)
- Tofacitinib Impurity 133 (CAS 10132-07-7)
- Tofacitinib Impurity 182 (CAS 1053228-28-6)
- Tofacitinib Impurity 123 DiHCl (CAS 1062580-52-2)
- Tofacitinib Impurity 20 (CAS 1092578-43-2)
- Tofacitinib Impurity 38 (CAS 1092578-45-4)
- Tofacitinib Impurity 1 (CAS 1092578-46-5)
- Tofacitinib Impurity 3 (CAS 1092578-47-6)
Recommended Standards
- Vigabatrin Impurity 17 HCl (CAS 213758-47-5（free base）)
- Norfloxacin Impurity 34 (CAS CATO-C4X-146834)
- Etomidate Impurity 74 (CAS CATO-C4X-188474)
- (2-Chloro-4-(trifluoromethyl)phenyl)methanamine (CAS 581813-20-9)
- n-((1h-Imidazol-2-yl)methyl)-2-(cyclohex-1-en-1-yl)ethan-1-amine (CAS 1251087-86-1)
- 4-Phenylazepan-4-ol (CAS 1202-87-5)
- MEthyl 4'-chloro[1,1'-biphenyl]-3-carboxylate (CAS 773134-21-7)
- Methyl 5,6-dihydroxyindoline-2-carboxylate (CAS 90922-83-1)
- 5-((3-(3,4-Dimethoxyphenyl)-1-phenyl-1H-pyrazol-4-yl)methylene)-3-isopropyl-2-thioxothiazolidin-4-one (CAS 623935-77-3)
- D-[His]1-Semaglutide (CAS CATO-C4X-222652)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com