N-(2,4-Dichlorophenyl)-6-hydroxy-1-methyl-2-oxo-1,2-dihydro-4-pyrimidinecarboxamide CAS 861208-48-2
| CAS No. | 861208-48-2 |
| Molecular Formula | C12H9Cl2N3O3 |
| Molecular Weight | 314.12 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of N-(2,4-Dichlorophenyl)-6-hydroxy-1-methyl-2-oxo-1,2-dihydro-4-pyrimidinecarboxamide is closely related to a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
CATO supplies N-(2,4-Dichlorophenyl)-6-hydroxy-1-methyl-2-oxo-1,2-dihydro-4-pyrimidinecarboxamide (CAS 861208-48-2), a certified reference material (molecular formula C12H9Cl2N3O3, MW 314.12 g/mol) for analytical method development and quality control.
The molecular framework of N-(2,4-Dichlorophenyl)-6-hydroxy-1-methyl-2-oxo-1,2-dihydro-4-pyrimidinecarboxamide (C12H9Cl2N3O3) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), N-(2,4-Dichlorophenyl)-6-hydroxy-1-methyl-2-oxo-1,2-dihydro-4-pyrimidinecarboxamide meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C12H9Cl2N3O3 |
| Molecular Weight | 314.12 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1987 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 3 |
Related N Standards
- 6-Acetyl-2-(3,5-dichlorophenyl)-4-methyl-1,2,4-triazine-3,5(2H,4H)-dione (CAS 477854-32-3)
- N-(2,3-Dichlorophenyl)-6-hydroxy-1-methyl-2-oxo-1,2-dihydro-4-pyrimidinecarboxamide (CAS 338774-73-5)
- N-(2,5-Dichlorophenyl)-6-hydroxy-1-methyl-2-oxo-1,2-dihydro-4-pyrimidinecarboxamide (CAS 338774-72-4)
- N-(3,4-Dichlorophenyl)-6-hydroxy-1-methyl-2-oxo-1,2-dihydropyrimidine-4-carboxamide (CAS 861208-54-0)
- 5-(2,4-Dichlorophenyl)-N-(2-hydroxyethyl)-2-methylfuran-3-carboxamide (CAS 875286-75-2)
- Ethyl 3-(2,4-dichlorophenyl)-2-(1,2-oxazol-5-yl)propanoate (CAS 672949-13-2)
- Methyl 3-(2,6-dichlorophenyl)-5-isopropylisoxazole-4-carboxylate (CAS 278597-28-7)
- 2-(3,4-Dichlorophenyl)naphtho[1,2-d]oxazole (CAS 1415985-98-6)
Recommended Standards
- Ethyl 4-(3,4-dichloro-2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)benzoate (CAS 65833-17-2)
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- 5-(Benzyloxy)-4-iodo-1-methyl-1H-pyrazole (CAS 2663667-27-2)
- Resmetirom Impurity 37 (CAS CATO-C4X-291237)
- (R)-1-(Tetrahydro-2H-pyran-4-yl)pyrrolidin-3-amine (CAS 1044305-89-6)
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- 2-(2-Hydroxyethyl)-7-nitro-2H-benzo[b][1,4]oxazin-3(4H)-one (CAS 191096-41-0)
- N*1*-(6-Morpholin-4-yl-3-nitro-4-trifluoromethyl-pyridin-2-yl)-propane-1,3-diamine (CAS 1089330-47-1)
- 3-Fluoro-N-(thiophen-3-ylmethyl)benzenesulfonamide (CAS 1060229-94-8)
- Ethyl 2-(methylcarbamoyl)isonicotinate (CAS 332013-42-0)
- p-Mentha-1,8(10)-dien-9-yl acetate (CAS 15111-97-4)
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