Gefitinib Impurity 75 CAS CATO-C4X-111775
| CAS No. | CATO-C4X-111775 |
| Molecular Formula | C15H11Cl2N3O2 |
| Molecular Weight | 336.17 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Gefitinib Impurity 75.
CATO supplies Gefitinib Impurity 75 (CAS CATO-C4X-111775), a pharmacopoeial impurity reference standard (molecular formula C15H11Cl2N3O2, MW 336.17 g/mol) used for the identification and quantification of trace impurities in APIs.
Based on its molecular formula C15H11Cl2N3O2, Gefitinib Impurity 75 contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 336.17 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Gefitinib Impurity 75 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C15H11Cl2N3O2 |
| Molecular Weight | 336.17 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 11.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 3 |
Related Gefitinib Standards
- Gefitinib Impurity 50 (CAS 199327-59-8)
- Gefitinib Impurity 19 (CAS 153437-78-6)
- Gefitinib Impurity 20 (CAS 690206-97-4)
- Gefitinib impurity 66 (CAS CATO-C4X-111766)
- Gefitinib Impurity 94 (CAS CATO-C4X-111794)
- Gefitinib Impurity 29 (CAS 861453-16-9)
- Gefitinib Impurity 24 (CAS CATO-C4X-111724)
- Gefitinib Impurity 59 (CAS CATO-C4X-111759)
Recommended Standards
- 951884-35-8 3,5-Dimethyl-3'-iodobenzophenone MFCD07775722 (CAS 951884-35-8)
- Hydrochlorothiazide Impurity 37 (CAS CATO-C4X-117737)
- 951884-33-6 3,5-Dimethyl-2'-iodobenzophenone MFCD07775704 (CAS 951884-33-6)
- Hydrochlorothiazide Impurity 38 (CAS CATO-C4X-117738)
- Flomoxef Impurity 28 (CAS CATO-C4X-138228)
- Upadacitinib Impurity 213 (CAS 2768445-19-6)
- Progesterone Impurity 39 (CAS 2645-92-3)
- 2-Methoxyethyl 2-amino-4-(2,3-dichlorophenyl)-6-(hydroxymethyl)-8-oxo-4,8-dihydropyrano[3,2-b]pyran-3-carboxylate (CAS 902304-37-4)
- 2-(5-Chloro-2-nitropyridin-3-yl)acetic acid (CAS 1804891-08-4)
- Bis(iodomethyl)(methyl)phosphine oxide (CAS 13916-01-3)
- Methyl 4-formylbicyclo[2.2.1]heptane-1-carboxylate (CAS 1628749-42-7)
- Methyl 2-[4-(3-piperidinylmethoxy)phenyl]acetate (CAS 946787-47-9)
- 4-(2-Chlorophenyl)-1,2,3-thiadiazol-5-amine (CAS 1538121-87-7)
- Semaglutide Impurity 186 (CAS CATO-C4X-2226186)
Why CATO?
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