Gefitinib Impurity 20 CAS 690206-97-4
| CAS No. | 690206-97-4 |
| Molecular Formula | C16H13ClFN3O2 |
| Molecular Weight | 333.74 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Gefitinib Impurity 20 (C16H13ClFN3O2) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
As a process- or degradation-related impurity, Gefitinib Impurity 20 (CAS 690206-97-4, C16H13ClFN3O2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Gefitinib Impurity 20 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C16H13ClFN3O2 |
| Molecular Weight | 333.74 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 11.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1985 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 3 |
Related Gefitinib Standards
- Gefitinib Impurity 19 (CAS 153437-78-6)
- Gefitinib impurity 66 (CAS CATO-C4X-111766)
- Gefitinib Impurity 94 (CAS CATO-C4X-111794)
- Gefitinib Impurity 24 (CAS CATO-C4X-111724)
- Gefitinib Impurity 75 (CAS CATO-C4X-111775)
- Gefitinib Impurity 50 (CAS 199327-59-8)
- Gefitinib Impurity 29 (CAS 861453-16-9)
- Gefitinib Impurity 49 (CAS 214472-41-0)
Recommended Standards
- (2-Chloro-benzyl)-(3-pentafluoroethylsulfanyl-propyl)-amine (CAS 1208079-00-8)
- 6-(2-Chloro-4-fluorobenzyl)-5,7-dimethylpyrazolo[1,5-a]pyrimidine-3-carboxylic acid (CAS 656817-42-4)
- 2-(2,2,2-trifluoroacetyl)-1,2,3,4-tetrahydroisoquinoline-7-sulfonyl chloride (CAS 74291-57-9)
- (2E)-N-[3-Chloro-5-(trifluoromethyl)pyridin-2-yl]-3-(pyrrolidin-1-yl)but-2-enamide (CAS 338397-34-5)
- Primidone EP Impurity E (CAS 90-27-7)
- Palbociclib Impurity 66 (CAS 193902-78-2)
- Palbociclib Impurity 46 (CAS 1244949-62-9)
- Mc-Val-Ala-PAB (CAS 1870916-87-2)
- Aldimorph (CAS 91315-15-0)
- N-(3-Cyano-5-phenylfuran-2-yl)-2-methylpropanamide (CAS 453590-29-9)
- Ethyl 6-(3-fluorobenzyl)-5,7-dimethylpyrazolo[1,5-a]pyrimidine-3-carboxylate (CAS 478064-86-7)
- 1-(3-Fluoro-4-methylphenyl)-1h-pyrazole-3-carboxylic acid (CAS 1152535-26-6)
- Methyl 2-(5-cyano-1-methyl-1H-indol-3-yl)acetate (CAS 796856-92-3)
- Fragment-[3-31]-Semaglutide (CAS CATO-C4X-2226113)
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