Ganciclovir Impurity 36 CAS 86357-10-0
| CAS No. | 86357-10-0 |
| Molecular Formula | C10H16O7 |
| Molecular Weight | 248.23 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Ganciclovir Impurity 36.
As a process- or degradation-related impurity, Ganciclovir Impurity 36 (CAS 86357-10-0, C10H16O7) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Structurally, Ganciclovir Impurity 36 (C10H16O7) contains a carboxylic acid group, a hydroxyl group, an ether linkage. The molecule exhibits a degree of unsaturation (DBE) of 3.0, corresponding to approximately 3 ring(s) or double-bond equivalent(s). With a molecular weight of 248.23 g/mol, it falls into the medium-molecular-weight range. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C10H16O7 |
| Molecular Weight | 248.23 g/mol |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), keep sealed and dry |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 3.0 |
| UV Absorption | UV-absorbing |
| CAS Registry Year (est.) | 1981 |
Related Ganciclovir Standards
- Ganciclovir impurity 21 (CAS CATO-C4X-102121)
- Ganciclovir EP Impurity E (CAS 86357-09-7)
- Ganciclovir EP Impurity H (CAS 84222-50-4)
- Ganciclovir (CAS 82410-32-0)
- Ganciclovir EP Impurity A (CAS 1797982-93-4)
- Ganciclovir-d5 (CAS 1189966-73-1)
- Ganciclovir Impurity 24 (CAS 86761-37-7)
- Ganciclovir EP Impurity C (CAS 108436-36-8)
Recommended Standards
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- Apixaban Impurity 87 (CAS CATO-C4X-108887)
- Ivabradine impurity 74 (CAS CATO-C4X-111974)
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- Rivaroxaban Impurity 25 (CAS 2648-71-7)
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- Fibrinogen Related Peptide (CAS 80755-86-8)
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