Diltiazem EP Impurity D CAS 86408-45-9
| CAS No. | 86408-45-9 |
| Molecular Formula | C21H24N2O4S |
| Molecular Weight | 400.49 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
CATO manufactures Diltiazem EP Impurity D under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Diltiazem EP Impurity D (CAS 86408-45-9) is a certified pharmaceutical impurity reference standard with the molecular formula C21H24N2O4S and a molecular weight of 400.49 g/mol.
Based on its molecular formula C21H24N2O4S, Diltiazem EP Impurity D contains a flavonoid core, an amide group, a sulfone group, a hydroxyl group, an ether linkage; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 400.49 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Physical & Chemical Properties
| Molecular Formula | C21H24N2O4S |
| Molecular Weight | 400.49 g/mol |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 11.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1981 |
| Nitrogen Atoms | 2 |
| Sulfur Atoms | 1 |
Related Diltiazem Standards
- Diltiazem - Impurity C (Freebase) (CAS 84903-78-6)
- Diltiazem N-Oxide O-Desacetyl Impurity (CAS 122619-90-3)
- Diltiazem Impurity 17 (CAS CATO-C4X-136817)
- Diltiazem (CAS 42399-41-7)
- Diltiazem D4 (CAS 112259-41-3)
- Diltiazem D6 (CAS 1242184-41-3)
- Diltiazem Impurity 16 (CAS 3036581-85-5)
- Diltiazem Sulfoxide (CAS 370094-12-5)
Recommended Standards
- Fmoc-Cysteinol(acm) (CAS 198543-46-3)
- 6-Hexyl-7-hydroxy-3-(4-methylbenzenesulfonyl)-2H-chromen-2-one (CAS 904438-98-8)
- N-(4-Methoxy-3-(2-oxopyrrolidin-1-yl)phenyl)-5,6,7,8-tetrahydronaphthalene-2-sulfonamide (CAS 941918-32-7)
- 4-(4-Butyl-3-methyl-2,5-dioxo-3-phenylpyrrolidin-1-yl)benzenesulfonamide (CAS 28103-49-3)
- Meglumine Impurity 14 (CAS CATO-C4X-214214)
- Relugoli Impurity 140 (CAS CATO-C4X-2429140)
- Policresulen Impurity 16 (CAS 17011-26-6)
- 3-[(4-Ethoxy-1,4-dioxobutyl)amino]-2-pyridinecarboxylic Acid Ethyl Ester (CAS 676596-61-5)
- 1-(Pyridin-4-yl)cyclopropanecarbonitrile (CAS 288379-77-1)
- 3-amino-N-{1-azabicyclo[2.2.2]octan-3-yl}benzene-1-sulfonamide (CAS 953755-87-8)
- Methyl 2-bromo-5-chlorothiazole-4-carboxylate (CAS 1053655-63-2)
- 1-Chloro-3-fluoro-2-iodobenzene (CAS 127654-70-0)
- tert-Butyl 3-amino-1-oxa-6-azaspiro[3.3]heptane-6-carboxylate (CAS 1349199-65-0)
- Tirzepatide Impurity 61 (CAS CATO-C4X-324061)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com