Vincristine Impurity N1 CAS 947527-73-3
| CAS No. | 947527-73-3 |
| Molecular Formula | C46H56N4O11 |
| Molecular Weight | 840.96 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
As a process- or degradation-related impurity, Vincristine Impurity N1 (CAS 947527-73-3, C46H56N4O11) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Vincristine Impurity N1 (C46H56N4O11) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage. It is notably hygroscopic, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
Physical & Chemical Properties
| Molecular Formula | C46H56N4O11 |
| Molecular Weight | 840.96 g/mol |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 21.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1987 |
| Nitrogen Atoms | 4 |
Related Vincristine Standards
- Vincristine EP Impurity A (CAS CATO-C4X-20891)
- Vincristine Impurity 15 (CAS CATO-C4X-208915)
- Vincristine Impurity 20 (CAS CATO-C4X-208920)
- Vincristine Impurity 19 (CAS CATO-C4X-208919)
- Vincristine Impurity 21 (CAS CATO-C4X-208921)
- Vincristine Impurity 18 (CAS CATO-C4X-208918)
- Vincristine EP Impurity G (CAS CATO-C4X-20897)
- Vincristine EP Impurity H (CAS 865-21-4)
Recommended Standards
- A-71623 (CAS 130408-77-4)
- 396718-26-6 Mca-Arg-Pro-Lys-Pro-Gln-OH MFCD01318846 (CAS 396718-26-6)
- PC Biotin-PEG3-NHS ester (CAS 2353409-93-3)
- (S)-O-[2-(Acetylamino)-3-O-benzoyl-2-deoxy-4,6-O-benzylidene-α-D-galactopyranosyl]-N-9-Fmoc-L-serine Phenacyl Ester (CAS 171973-67-4)
- Glycine Impurity 6 (CAS CATO-C4X-33366)
- Flurbiprofen Impurity 46 (CAS CATO-C4X-144446)
- Carvedilol impurity 21 (CAS 1261395-96-3)
- Ethyl 5-(phenylamino)thiazole-4-carboxylate (CAS 1410092-36-2)
- 5-Bromo-2,1-benzothiazole-3-carboxylic acid (CAS 1367452-90-1)
- {3-[5-(4-fluorophenyl)-1-methyl-1h-pyrazol-3-yl]propyl}(methyl)amine dihydrochloride (CAS 1193387-68-6)
- 3-Phenyl-3-trifluoromethylpropiophenone (CAS 67082-01-3)
- (4-Chloro-3-(m-tolylcarbamoyl)phenyl)boronic acid (CAS 1449131-69-4)
- (S)-2-Amino-N-isopropyl-3-methyl-N-(2-methylbenzyl)butanamide (CAS 1354018-27-1)
- Insulin aspart (CAS 116094-23-6)
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