2-Benzylidene-N1,N3-bis(4-(trifluoromethyl)phenyl)malonamide CAS 866008-58-4
| CAS No. | 866008-58-4 |
| Molecular Formula | C24H16F6N2O2 |
| Molecular Weight | 478.39 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of 2-Benzylidene-N1,N3-bis(4-(trifluoromethyl)phenyl)malonamide is closely related to a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
2-Benzylidene-N1,N3-bis(4-(trifluoromethyl)phenyl)malonamide (CAS 866008-58-4), molecular formula C24H16F6N2O2 and molecular weight 478.39 g/mol, is a CATO reference standard with documented purity and traceability.
2-Benzylidene-N1,N3-bis(4-(trifluoromethyl)phenyl)malonamide (C24H16F6N2O2) contains a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), 2-Benzylidene-N1,N3-bis(4-(trifluoromethyl)phenyl)malonamide meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C24H16F6N2O2 |
| Molecular Weight | 478.39 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 15.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1987 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 2 |
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Recommended Standards
- 1-(4-Methoxybenzyl)-3-(((4-methoxybenzyl)oxy)methyl)-5-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole (CAS 2489244-20-2)
- 4,4'-(Naphthalene-2,7-diylbis(oxy))bis(3-(trifluoromethyl)aniline) (CAS 583829-58-7)
- (8E)-2-Amino-4-[2-(trifluoromethyl)phenyl]-8-{[2-(trifluoromethyl)phenyl]methylidene}-4H,5H,7H,8H-pyrano[3,2-c]pyran-3-carbonitrile (CAS 445390-77-2)
- Crizotinib Impurity 59 (CAS CATO-C4X-102559)
- 4-(3-Difluoromethoxyphenyl)thiosemicarbazide (CAS 1263376-22-2)
- (S)-2-((tert-Butoxycarbonyl)amino)-3-(2-fluoro-4-hydroxyphenyl)propanoic acid (CAS 125218-32-8)
- 1-((1-Ethyl-3-methyl-1h-pyrazol-5-yl)methyl)-1h-1,2,3-triazol-4-amine (CAS 1512638-84-4)
- 6-Bromo-4-methyl-3,4-dihydro-2H-pyrido[3,2-b][1,4]oxazine (CAS 1519666-61-5)
- 1-(4-Bromophenyl)-2-(triphenyl-l5-phosphaneylidene)ethan-1-one (CAS 1777-57-7)
- 4,4'-(Ethyne-1,2-diyl)bis(2-propoxybenzohydrazide) (CAS 2413016-99-4)
- 2,5-Difluoro-3-methylbenzyl bromide (CAS 1804417-86-4)
- (5-Ethyl-2-methoxyphenyl)acetic acid (CAS 383134-25-6)
- 1-((6,7-Dimethoxynaphthalen-2-yl)methyl)-6,7-dimethoxy-3,4-dihydroisoquinoline (CAS 37708-04-6)
- (Pro3)-Gastric Inhibitory Polypeptide (human) trifluoroacetate salt (CAS 299898-52-5)
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