Crizotinib Impurity 59 CAS CATO-C4X-102559
| CAS No. | CATO-C4X-102559 |
| Molecular Formula | C23H26Cl2FN5O |
| Molecular Weight | 478.39 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Crizotinib Impurity 59 is closely related to a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
Crizotinib Impurity 59 (CAS CATO-C4X-102559) is a certified pharmaceutical impurity reference standard with the molecular formula C23H26Cl2FN5O and a molecular weight of 478.39 g/mol.
Crizotinib Impurity 59 (C23H26Cl2FN5O) contains a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. Halogen substitution raises its density and boiling point; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C23H26Cl2FN5O |
| Molecular Weight | 478.39 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at room temperature, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 5 |
Related Crizotinib Standards
- Crizotinib Impurity 43 (CAS CATO-C4X-102543)
- Crizotinib impurity 12 (CAS CATO-C4X-102512)
- Crizotinib impurity 13 (CAS CATO-C4X-102513)
- Crizotinib impurity 21 (CAS CATO-C4X-102521)
- Crizotinib impurity 25 (CAS CATO-C4X-102525)
- Crizotinib Impurity 57 (CAS CATO-C4X-102557)
- Crizotinib Impurity 58 (CAS CATO-C4X-102558)
- Crizotinib 2-Keto Impurity (CAS 1415558-82-5)
Recommended Standards
- 4,4'-(Naphthalene-2,7-diylbis(oxy))bis(3-(trifluoromethyl)aniline) (CAS 583829-58-7)
- Hesperetin 3’-O-Beta-D-Glucuronide (CAS 150985-66-3)
- 2-Benzylidene-N1,N3-bis(4-(trifluoromethyl)phenyl)malonamide (CAS 866008-58-4)
- 3-((2S,5S)-5-((3R,5R)-3-Hydroxy-6-iodo-5-methylhept-6-en-1-yl)-4-methylenetetrahydrofuran-2-yl)propyl pivalate (CAS 157322-47-9)
- N-Nitroso Moxifloxacin EP Impurity G (CAS CATO-C4X-1074125)
- Phenytoin impurity 5 (CAS 3254-93-1)
- Peramivir Impurity 22 HCl (CAS CATO-C4X-183322)
- 2-Bromo-N-(tert-butyl)benzenesulfonamide (CAS 138733-50-3)
- IDIC-2F (CAS 2412911-52-3)
- 2-Phenethylmalonic acid (CAS 3709-21-5)
- Hexahydro-1H-pyrrolizine-2-carboxylic acid (CAS 342411-93-2)
- 4-amino-1-phenylbutan-1-one oxime hydrochloride (CAS 1173402-64-6)
- Fmoc-aminooxy-PEG4-acid (CAS 1895922-70-9)
- [y-Glu15]-Semaglutide Impurity 134 (CAS CATO-C4X-2226134)
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