1-[(3-Bromophenyl)methyl]-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-2-one CAS 866010-23-3
| CAS No. | 866010-23-3 |
| Molecular Formula | C22H17BrN2O |
| Molecular Weight | 405.29 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of 1-[(3-Bromophenyl)methyl]-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-2-one is closely related to a steroid core, an amide group, a hydroxyl group, an ether linkage, bromine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
1-[(3-Bromophenyl)methyl]-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-2-one (CAS 866010-23-3), molecular formula C22H17BrN2O and molecular weight 405.29 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of 1-[(3-Bromophenyl)methyl]-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-2-one (C22H17BrN2O) is characterized by a steroid core, an amide group, a hydroxyl group, an ether linkage, bromine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), 1-[(3-Bromophenyl)methyl]-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-2-one meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C22H17BrN2O |
| Molecular Weight | 405.29 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at room temperature, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 15.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1987 |
| Halogen Content | Br-containing |
| Nitrogen Atoms | 2 |
Related Bromophenyl Standards
- 2-[(4-Bromophenyl)carbamoyl]thiophen-3-yl N,N-dimethylsulfamate (CAS 338794-39-1)
- 4-(4-Bromophenyl)-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinoline-8-sulfonamide (CAS 360791-49-7)
- 2-((3-(4-Bromophenyl)-4-oxo-3,4-dihydroquinazolin-2-yl)thio)acetohydrazide (CAS 133764-46-2)
- 2-{[4-(4-bromophenyl)-5-(pyridin-4-yl)-4h-1,2,4-triazol-3-yl]sulfanyl}acetohydrazide (CAS 893727-33-8)
- N-(2-Bromophenyl)-2-((3-(2-hydroxyphenyl)-1H-1,2,4-triazol-5-yl)thio)acetamide (CAS 336180-29-1)
- 4-(4-((4-Bromophenyl)sulfonyl)piperazin-1-yl)-4-oxobutanoic acid (CAS 893725-68-3)
- 3-{[(4-bromophenyl)sulfanyl]methyl}-2H,3H,5H-[1,3]thiazolo[2,3-b]quinazolin-5-one (CAS 477860-18-7)
- 1-(4-Bromophenyl)-3-((2,3,4,5,6-pentamethylbenzyl)thio)propan-1-one (CAS 882749-14-6)
Recommended Standards
- (S)-Methyl 2-((tert-butoxycarbonyl)amino)-3-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)propanoate (CAS 220587-29-1)
- 1-Piperidinecarboxylic acid, 4-(5-bromo-7-cyano-1h-indazol-3-yl)-, 1,1-dimethylethyl ester (CAS 872350-11-3)
- (R)-2-tert-Butoxycarbonylamino-3-[4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenyl]-propionic acid methyl ester (CAS 335030-24-5)
- 2-(4-(8-Bromo-2-methyl-1H-imidazo[4,5-c]quinolin-1-yl)phenyl)-2-methylpropanenitrile (CAS 1624261-99-9)
- 1,2-Diisopropoxybenzene (CAS 1698-98-2)
- 3-Ethynyl-1h-indole (CAS 62365-78-0)
- (6-(2,2,2-Trifluoroethoxy)pyridin-3-yl)methanamine (CAS 771584-26-0)
- Aripiprazole Impurity 77 (CAS CATO-C4X-100877)
- 2-Methyldibenzo[f,h]quinoxaline (CAS 536753-86-3)
- 3-Aminopyridazine-4-carboximidhydrazide (CAS 137609-33-7)
- 7-Oxo Cholesterol 3-Acetate (CAS 809-51-8)
- 2-(Pyrimidin-5-yl)propanoic acid (CAS 691845-51-9)
- 4-(4-Chlorophenyl)-2-sulfanyl-4,5-dihydro-1H-imidazol-5-one (CAS 1551779-08-8)
- Biotinyl-Neuropeptide Y (human, rat) trifluoroacetate salt (CAS 213779-13-6)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com