(5E)-5-[(Furan-2-yl)methylidene]-2-(4-hydroxypiperidin-1-yl)-4,5-dihydro-1,3-thiazol-4-one CAS 866133-41-7
| CAS No. | 866133-41-7 |
| Molecular Formula | C13H14N2O3S |
| Molecular Weight | 278.33 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
(5E)-5-[(Furan-2-yl)methylidene]-2-(4-hydroxypiperidin-1-yl)-4,5-dihydro-1,3-thiazol-4-one (C13H14N2O3S) contains a nitrogen-containing heterocyclic scaffold, an amide group, a sulfone group, a hydroxyl group, an ether linkage. It is notably hygroscopic, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
(5E)-5-[(Furan-2-yl)methylidene]-2-(4-hydroxypiperidin-1-yl)-4,5-dihydro-1,3-thiazol-4-one (CAS 866133-41-7), molecular formula C13H14N2O3S and molecular weight 278.33 g/mol, is a CATO reference standard with documented purity and traceability.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C13H14N2O3S |
| Molecular Weight | 278.33 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1987 |
| Nitrogen Atoms | 2 |
| Sulfur Atoms | 1 |
Related E Standards
- (E)-3-(furan-2-yl)-2-(4-phenylthiazol-2-yl)acrylonitrile (CAS 277308-31-3)
- 4-((Furan-2-ylmethylene)amino)-N,N-dimethylbenzenesulfonamide (CAS 30822-00-5)
- 3-Ethyl-5-(furan-2-yl)-2-sulfanyl-3h,4h-thieno[2,3-d]pyrimidin-4-one (CAS 852933-44-9)
- 4-(Furan-2-ylmethyl)-5-(3-methylpiperidin-1-yl)-4h-1,2,4-triazole-3-thiol (CAS 923805-80-5)
- 2-(7-(Furan-2-yl)-5-oxo-2,3-dihydro-5H-thiazolo[3,2-a]pyrimidin-3-yl)acetic acid (CAS 1411766-78-3)
- N-(5-(3-(Furan-2-yl)acryloyl)-4-hydroxythiazol-2-yl)acetamide (CAS 62041-07-0)
- Bis(furan-2-ylmethyl) succinate (CAS 94245-64-4)
- 3-(Furan-2-yl)-1-phenyl-5-(trifluoromethyl)-1H-pyrazole (CAS 193816-18-1)
Recommended Standards
- (3,5-Dimethylisoxazol-4-yl)methyl 2-(methylthio)nicotinate (CAS 556030-17-2)
- (2Z)-N-(2-methoxyphenyl)-2-(3-methyl-4-oxo-1,3-thiazolidin-2-ylidene)acetamide (CAS 733030-62-1)
- (E)-5-phenyl-2-((thiophen-2-ylmethylene)amino)furan-3-carbonitrile (CAS 478033-41-9)
- 2-(Naphthalene-2-sulfonyl)propanehydrazide (CAS 1797040-43-7)
- 2-Bromo-1-(tert-butyl)-4-cyclopropoxybenzene (CAS 1243470-93-0)
- 4-(Bromomethyl)-4-methylpiperidine (CAS 1996750-88-9)
- 7-Chloroquinolin-6-ol (CAS 1261561-19-6)
- Diethyl 2,2'-(1,3,6,8-tetraoxo-1,3,6,8-tetrahydrobenzo[lmn][3,8]phenanthroline-2,7-diyl)diacetate (CAS 64005-90-9)
- 3,5-Xylenol Phosphate (CAS 25653-16-1)
- tert-butyl 2-amino-2-(1-methyl-1H-pyrazol-5-yl)acetate (CAS 1909305-37-8)
- (S)-(-)-3-(3-Hydroxyphenyl)-N-propylpiperidine Hydrochloride (CAS 88768-67-6)
- 1-(2-Ethylphenyl)-5-phenyl-4,5-dihydro-1h-pyrazole-3-carboxylic acid (CAS 1264050-18-1)
- (S)-QUINUCLIDIN-3-YL (2-(2-(4-FLUOROPHENYL)THIAZOL-4-YL)PROPAN-2-YL)CARBAMATE (CAS 1401090-53-6)
- Semaglutide Impurity 12 (CAS CATO-C4X-222612)
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