3-{[3-chloro-5-(trifluoromethyl)pyridin-2-yl](methyl)amino}-1-[(E)-[(3-ethoxy-4-hydroxyphenyl)methylidene]amino]urea CAS 866149-29-3
| CAS No. | 866149-29-3 |
| Molecular Formula | C17H17ClF3N5O3 |
| Molecular Weight | 431.80 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 431.80 g/mol gives 3-{[3-chloro-5-(trifluoromethyl)pyridin-2-yl](methyl)amino}-1-[(E)-[(3-ethoxy-4-hydroxyphenyl)methylidene]amino]urea distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
3-{[3-chloro-5-(trifluoromethyl)pyridin-2-yl](methyl)amino}-1-[(E)-[(3-ethoxy-4-hydroxyphenyl)methylidene]amino]urea (CAS 866149-29-3) is a high-purity analytical reference standard with the molecular formula C17H17ClF3N5O3 and a molecular weight of 431.80 g/mol.
The molecular framework of 3-{[3-chloro-5-(trifluoromethyl)pyridin-2-yl](methyl)amino}-1-[(E)-[(3-ethoxy-4-hydroxyphenyl)methylidene]amino]urea (C17H17ClF3N5O3) is characterized by a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
CATO manufactures 3-{[3-chloro-5-(trifluoromethyl)pyridin-2-yl](methyl)amino}-1-[(E)-[(3-ethoxy-4-hydroxyphenyl)methylidene]amino]urea under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C17H17ClF3N5O3 |
| Molecular Weight | 431.80 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1987 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 5 |
Related chloro Standards
- 1-(4-Chloro-3-(trifluoromethyl)phenyl)-3-(3-(4-cyanophenoxy)phenyl)urea (CAS 1400989-25-4)
- 3-{[3-chloro-5-(trifluoromethyl)pyridin-2-yl](methyl)amino}-1-[(1E)-{[(4-methoxyphenyl)methoxy]amino}methylidene]urea (CAS 321433-46-9)
- N-(4-Chloro-3-(trifluoromethyl)phenyl)-3-(4-(pyridin-3-yloxy)phenyl)-1H-1,2,4-triazol-5-amine (CAS 877874-59-4)
- 2-(4-(3-Chloro-5-(trifluoromethyl)pyridin-2-yl)piperazin-1-yl)ethyl 4-fluorobenzoate (CAS 338415-48-8)
- Ethyl 2-(1-((3-chloro-5-(trifluoromethyl)pyridin-2-yl)methyl)-1H-1,2,3-triazol-4-yl)-5-methylthiazole-4-carboxylate (CAS 1823182-96-2)
- 1-[3-Chloro-5-(trifluoromethyl)pyridin-2-yl]-N-(4-methoxyphenyl)-1H-pyrrole-2-sulfonamide (CAS 321433-66-3)
- 3-(3-(3-(2-Chloro-4-nitrophenoxy)propyl)ureido)benzene-1-sulfonyl fluoride (CAS 25240-52-2)
- N-(3-chloro-4-fluorophenyl)-2-((3-cyano-6-ethyl-5-methyl-4-(trifluoromethyl)pyridin-2-yl)thio)acetamide (CAS 664999-23-9)
Recommended Standards
- Ethyl N-[(2E)-2-({4-[3-chloro-5-(trifluoromethyl)pyridin-2-yl]piperazin-1-yl}methylidene)-2-cyanoacetyl]carbamate (CAS 338979-07-0)
- N-(3-(3-chlorophenoxy)-5-nitrophenyl)-2-(5-methyl-3-nitro-1H-pyrazol-1-yl)acetamide (CAS 321142-91-0)
- N-[p-(Acetylmercuric)phenyl]maleimide (CAS 117259-61-7)
- Ethyl 2-(3-{[3-chloro-5-(trifluoromethyl)pyridin-2-yl](methyl)amino}-5-cyano-2,6-dioxo-1,2,3,6-tetrahydropyrimidin-1-yl)acetate (CAS 338399-47-6)
- 2-(3-Chloro-4-oxazol-2-yl-benzoyl)-3-hydroxy-cyclohex-2-enone (CAS 1231606-47-5)
- Polyphenylmethyldimethylsiloxane, average M.W. 2500 - 2700 (CAS 9005-12-3)
- (R)-1-Tritylaziridine-2-carboxylic acid (CAS 1942918-74-2)
- 4,6-Dimethyl-3(2H)-pyridazinone (CAS 7007-92-3)
- 4-Bromo-5-(difluoromethyl)-3-fluoropyridine-2-acetic acid (CAS 1805402-25-8)
- S-(2-Chloro-2-propen-1-yl) ethanethioate (CAS 24891-77-8)
- Chromium(VI) trioxide (CAS 1333-82-0)
- 4-Hydroxy-2-mercapto-6-(trifluoromethyl)pyrimidine (CAS 368-54-7)
- Dehydro Mefloquine-d5 (CAS 1246819-32-8)
- Palmitoyl Tripeptide-1 TFA salt (CAS 2803375-47-3)
Why CATO?
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