(2Z)-2,3-Dichloro-N-(6-methoxypyridin-3-yl)-3-[(4-methylphenyl)methanesulfonyl]prop-2-enamide CAS 1164529-74-1
| CAS No. | 1164529-74-1 |
| Molecular Formula | C17H16Cl2N2O4S |
| Molecular Weight | 415.29 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
(2Z)-2,3-Dichloro-N-(6-methoxypyridin-3-yl)-3-[(4-methylphenyl)methanesulfonyl]prop-2-enamide (CAS 1164529-74-1) is a high-purity analytical reference standard with the molecular formula C17H16Cl2N2O4S and a molecular weight of 415.29 g/mol.
The molecular framework of (2Z)-2,3-Dichloro-N-(6-methoxypyridin-3-yl)-3-[(4-methylphenyl)methanesulfonyl]prop-2-enamide (C17H16Cl2N2O4S) is characterized by a flavonoid core, an amide group, a sulfone group, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C17H16Cl2N2O4S |
| Molecular Weight | 415.29 g/mol |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1989 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
| Sulfur Atoms | 1 |
Related Z Standards
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- (3E)-3-{2-[2,6-dichloro-4-(trifluoromethyl)phenyl]hydrazin-1-ylidene}-1-(propan-2-yl)-2,3-dihydro-1H-indol-2-one (CAS 320422-22-8)
- N-(2,2-Dichloro-1-(diphenylphosphoryl)vinyl)benzamide (CAS 55785-68-7)
- 3,6-Dichloro-N-(4-phenoxyphenyl)benzo[b]thiophene-2-carboxamide (CAS 332156-21-5)
- 3,5-Dichloro-4-methoxy-N-(4-(oxazolo[4,5-b]pyridin-2-yl)phenyl)benzamide (CAS 710284-99-4)
- (3E)-3-{2-[2,6-dichloro-4-(trifluoromethyl)phenyl]hydrazin-1-ylidene}-1-(prop-2-en-1-yl)-2,3-dihydro-1H-indol-2-one (CAS 320422-17-1)
- (S)-2-(4-((4,6-Dichloro-1,3,5-triazin-2-yl)amino)benzamido)pentanedioic acid (CAS 113900-52-0)
Recommended Standards
- 2-({[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl]amino}methylidene)-2,3-dihydro-1H-indene-1,3-dione (CAS 1023531-54-5)
- Eltrombopag Impurity 106 (CAS CATO-C4X-1198106)
- 4,6-Bis[3-(trifluoromethyl)phenoxy]pyrimidin-2-amine (CAS 866154-31-6)
- N-(4-Bromophenyl)-1-butyl-4-hydroxy-2-oxo-1,2-dihydroquinoline-3-carboxamide (CAS 303093-29-0)
- Ethyl 3-(4-aminopyridin-3-yl)benzoate (CAS 1258626-32-2)
- 1-(3-(Methylamino)-4-nitro-1H-pyrazol-1-yl)ethan-1-one (CAS 318517-42-9)
- (2R,6S)-2,6-DImethyl-1-(2-pyrrolidinylmethyl)piperidine (CAS 956266-23-2)
- N-Trityl Candesartan Cilexetil Methoxy Analogue (CAS 1797867-82-3)
- 1-(1-Methyl-1H-indazol-3-yl)ethanone (CAS 69271-42-7)
- (R)-6-methylchroman-4-amine (CAS 756818-55-0)
- (E)-3-(4-(3-fluoropropoxy)phenyl)acrylic acid (CAS 695186-85-7)
- 7-Amino-1,2,3,4-tetrahydroisoquinoline Hydrochloride (CAS 175871-45-1)
- 2-Fluoro-N-(4-hydroxy-2-methylphenyl)benzamide (CAS 791832-43-4)
- Semaglutide impurity 248 (CAS CATO-C4X-2226248)
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