(5E)-5-[(2-Fluorophenyl)methylidene]-2-(methylsulfanyl)-4,5-dihydro-1,3-thiazol-4-one CAS 866154-46-3
| CAS No. | 866154-46-3 |
| Molecular Formula | C11H8FNOS2 |
| Molecular Weight | 253.32 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The molecular framework of (5E)-5-[(2-Fluorophenyl)methylidene]-2-(methylsulfanyl)-4,5-dihydro-1,3-thiazol-4-one (C11H8FNOS2) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, sulfur-containing functionality, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
(5E)-5-[(2-Fluorophenyl)methylidene]-2-(methylsulfanyl)-4,5-dihydro-1,3-thiazol-4-one (CAS 866154-46-3), molecular formula C11H8FNOS2 and molecular weight 253.32 g/mol, is a CATO reference standard with documented purity and traceability.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
CATO manufactures (5E)-5-[(2-Fluorophenyl)methylidene]-2-(methylsulfanyl)-4,5-dihydro-1,3-thiazol-4-one under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C11H8FNOS2 |
| Molecular Weight | 253.32 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1987 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
| Sulfur Atoms | 2 |
Related E Standards
- (5Z)-5-[(4-Fluorophenyl)methylidene]-2-(methylsulfanyl)-4,5-dihydro-1,3-thiazol-4-one (CAS 1544401-87-7)
- [4-(4-fluorophenyl)-1,3-thiazol-2-yl]thiourea (CAS 835910-55-9)
- 1-(4-Fluorophenyl)-3-(thiazol-2-yl)thiourea (CAS 457-82-9)
- 5-(4-Fluorophenyl)-4-(2-methoxyethyl)-2,4-dihydro-3H-1,2,4-triazole-3-thione (CAS 694461-58-0)
- 5-((3-Fluorophenyl)amino)-3,3-dimethyl-5-oxopentanoic acid (CAS 1011454-07-1)
- 3-(3-Fluorophenyl)-1-phenyl-1H-pyrazol-5-amine (CAS 1015844-72-0)
- 5-N-(4-fluorophenyl)isoquinoline-5,8-diamine (CAS 1153123-20-6)
- 4-(4-Fluorophenyl)-1-phenyl-1H-pyrazol-5-amine (CAS 1158528-62-1)
Recommended Standards
- (4-tert-Butylphenyl)benzoate (CAS 26459-51-8)
- (R)-4-Methyl-2-((3-sulfopropyl)amino)pentanoic acid (CAS 819864-24-9)
- (3-Hydroxy-4-methoxyphenyl)(morpholino)methanethione (CAS 23015-41-0)
- [4-(2-Pyridin-3-yl-1,3-thiazol-4-yl)phenyl]amine (CAS 92165-08-7)
- 4,4''-Bis(3,6-di-tert-butyl-9H-carbazol-9-yl)-[1,1':4',1''-terphenyl]-2',5'-dicarbaldehyde (CAS 2172631-09-1)
- 2-(2-Bromophenyl)-4,6-dichloropyrimidine (CAS 1188237-02-6)
- 5-Amino-2-(2-methoxyethyl)-1,2,4-thiadiazol-3(2H)-one (CAS 1365942-69-3)
- 2-Methylbenzimidazole-5,6-diol (CAS 51437-33-3)
- 6-Chloro-2-(o-tolyl)-4H-chromen-4-one (CAS 88952-76-5)
- 5-oxo-1-(2-pyridinyl)-3-Pyrrolidinecarboxylic acid hydrochloride (1:1) (CAS 1384427-91-1)
- 4-(3-Chloro-5-(trifluoromethyl)pyridin-2-yl)-4-(phenylsulfonyl)butanenitrile (CAS 338406-76-1)
- 4-(chloromethyl)-1-[(4-fluorophenyl)methyl]-1h-1,2,3-triazole (CAS 1248230-67-2)
- Methyl 4-((3,4-dinitro-1h-pyrazol-1-yl)methyl)benzoate (CAS 313062-84-9)
- Peptide Impurity 40 (CAS CATO-CPTD788840)
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