8-Chloro-2-ethynylquinoline CAS 866874-10-4
| CAS No. | 866874-10-4 |
| Molecular Formula | C11H6ClN |
| Molecular Weight | 187.63 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
8-Chloro-2-ethynylquinoline (CAS 866874-10-4) is a high-purity analytical reference standard with the molecular formula C11H6ClN and a molecular weight of 187.63 g/mol.
Owing to a nitrogen-containing heterocyclic scaffold, a nitrile group, chlorine substitution, 8-Chloro-2-ethynylquinoline is typically pale yellow to yellow low-melting solid. Its solid-state physicochemical attributes — including a molecular weight of 187.63 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), 8-Chloro-2-ethynylquinoline meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C11H6ClN |
| Molecular Weight | 187.63 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1987 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
Related Chloro Standards
- 2-Chloro-3-ethynylquinoline (CAS 1000782-65-9)
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Recommended Standards
- 6-Chloro-N2,N2,N4-trimethyl-1,3,5-triazine-2,4-diamine (CAS 71406-91-2)
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- 6-Chloro-N-(2-methoxyethyl)-4-pyrimidinamine (CAS 503610-76-2)
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