Carbamazepine Impurity 28 CAS 866873-98-5
| CAS No. | 866873-98-5 |
| Molecular Formula | C15H10Br3NO |
| Molecular Weight | 459.96 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a certified reference material (CRM), Carbamazepine Impurity 28 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Carbamazepine Impurity 28 (CAS 866873-98-5) is a certified pharmaceutical impurity reference standard with the molecular formula C15H10Br3NO and a molecular weight of 459.96 g/mol.
The molecular framework of Carbamazepine Impurity 28 (C15H10Br3NO) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, bromine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Physical & Chemical Properties
| Molecular Formula | C15H10Br3NO |
| Molecular Weight | 459.96 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | >95% |
| Storage | Store at room temperature, protect from light |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1987 |
| Halogen Content | Br-containing |
| Nitrogen Atoms | 1 |
Related Carbamazepine Standards
- Carbamazepine Impurity 6 (CAS 40421-03-2)
- Carbamazepine Impurity 29 (CAS 2512216-68-9)
- Carbamazepine Impurity 39 (CAS 53003-61-5)
- Carbamazepine Impurity 23 (CAS CATO-C4X-118123)
- Carbamazepine Impurity 17 (CAS CATO-C4X-118117)
- Carbamazepine Impurity 11 (CAS 33948-20-8)
- Carbamazepine Impurity 12 (CAS 143667-53-2)
- Carbamazepine Impurity 22 (CAS CATO-C4X-118122)
Recommended Standards
- 3-(2-Chlorophenyl)-N-((3,4-dimethoxyphenethyl)carbamothioyl)-5-methylisoxazole-4-carboxamide (CAS 883031-66-1)
- (S)-N-(1-(1H-Benzo[d]imidazol-2-yl)-4-(2-chloroacetimidamido)butyl)-[1,1'-biphenyl]-4-carboxamide (CAS 1802637-39-3)
- 3-(2-Chlorophenyl)-5-methyl-N-(4-(6-methylbenzo[d]thiazol-2-yl)phenyl)isoxazole-4-carboxamide (CAS 349613-51-0)
- (S)-tert-Butyl 1-(chloromethyl)-5-((4-methylpiperazine-1-carbonyl)oxy)-1H-benzo[e]indole-3(2H)-carboxylate (CAS 244154-66-3)
- Abemaciclib Impurity 189 (CAS CATO-C4X-2937189)
- Tirofiban Impurity 53 (CAS CATO-C4X-125453)
- Eplerenone Impurity 18(Sodium Salt) (CAS CATO-C4X-163018)
- 2-[(dimethylamino)methyl]-3-hydroxy-3-phenylpropanenitrile (CAS 343776-88-5)
- 2-(((1-((Benzyloxy)carbonyl)pyrrolidin-2-yl)methyl)(isopropyl)amino)acetic acid (CAS 1353975-45-7)
- 5-Ethyl-3-methylisoxazole-4-carbonyl chloride (CAS 144272-76-4)
- 2-(Cyclohexyloxy)-3-nitropyridine (CAS 147143-55-3)
- 1-(tert-Butyl) 2-methyl 4-bromo-3-chloro-1H-pyrrole-1,2-dicarboxylate (CAS 1629633-73-3)
- Ceftazidime dimer derivative 3 (CAS CATO-C4X-121269)
- D-Ala21-Tirzepatide (CAS CATO-CPTD788913)
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