Montelukast Impurity C167 CAS 866923-62-8
| CAS No. | 866923-62-8 |
| Molecular Formula | C35H35ClN2OS |
| Molecular Weight | 567.18 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
CATO supplies Montelukast Impurity C167 (CAS 866923-62-8), a pharmacopoeial impurity reference standard (molecular formula C35H35ClN2OS, MW 567.18 g/mol) used for the identification and quantification of trace impurities in APIs.
Montelukast Impurity C167 (C35H35ClN2OS) contains a nitrogen-containing heterocyclic scaffold, an amide group, sulfur-containing functionality, a hydroxyl group, an ether linkage, chlorine substitution. Halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C35H35ClN2OS |
| Molecular Weight | 567.18 g/mol |
| Purity | ≥95% |
| Storage | Store at room temperature, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 19.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1987 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
| Sulfur Atoms | 1 |
Related Montelukast Standards
- Montelukast EP Impurity B (CAS 918972-54-0)
- Montelukast EP Impurity F (CAS 937275-23-5)
- Montelukast Impurity 4 (CAS 1772578-77-4)
- Montelukast Impurity 2 (CAS CATO-C4X-10312)
- Montelukast Amide (CAS 866923-63-9)
- Montelukast EP Impurity H (CAS 851755-56-1)
- Montelukast Impurity 24 (CAS CATO-C4X-103124)
- Montelukast (CAS 158966-92-8)
Recommended Standards
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- Nifuratel Impurity 28 (CAS 22551-26-4)
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- Tofacitinib Impurity 194 (CAS CATO-C4X-1079194)
- 5-(4-fluorophenyl)-3-[(2,3,3-trichloroacryloyl)amino]thiophene-2-carboxamide (CAS 648410-18-8)
- Felodipine (CAS 72509-76-3)
- 3-{[(4-bromophenyl)methyl]sulfanyl}-5-({[(4-chlorophenyl)methyl]sulfanyl}methyl)-4-ethyl-4H-1,2,4-triazole (CAS 344268-63-9)
- 1-(Bromomethyl)-4-(4-methylphenoxy)benzene (CAS 78805-82-0)
- 1-Methyl-1H-imidazo[4,5-b]pyridin-5(4H)-one (CAS 915138-52-2)
- 5-Chloro-3-iodo-1-methyl-1H-pyrazolo[4,3-b]pyridine (CAS 1471262-95-9)
- Semaglutide impurity 95 (CAS CATO-C4X-222695)
Why CATO?
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