Carfilzomib Impurity 37 (Trifluoroacetic Acid) CAS 868539-99-5
| CAS No. | 868539-99-5 |
| Molecular Formula | C26H35N3O4 |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a certified reference material (CRM), Carfilzomib Impurity 37 (Trifluoroacetic Acid) meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
As a process- or degradation-related impurity, Carfilzomib Impurity 37 (Trifluoroacetic Acid) (CAS 868539-99-5, C26H35N3O4C2HF3O2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Structurally, Carfilzomib Impurity 37 (Trifluoroacetic Acid) (C26H35N3O4C2HF3O2) contains a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 11.0, corresponding to approximately 11 ring(s) or double-bond equivalent(s). With a molecular weight of 567.61 g/mol, it falls into the moderately-high-molecular-weight range. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Physical & Chemical Properties
| Molecular Formula | C26H35N3O4 C2HF3O2 |
| Molecular Weight | 567.61 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 11.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1987 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 3 |
Related Carfilzomib Standards
- CarfilzomiB impurity 12 (CAS 100564-78-1)
- Carfilzomib Impurity 36 (CAS 1140908-89-9)
- Carfilzomib Impurity 50 (CAS 129603-01-6)
- Carfilzomib Impurity N2 (CAS 1396006-45-3)
- Carfilzomib Impurity N1 (CAS 1396006-47-5)
- Carfilzomib Impurity 28 (CAS 143415-51-4)
- Carfilzomib Impurity 25 (CAS 15136-32-0)
- Carfilzomib Impurity 71 (CAS 1528769-14-3)
Recommended Standards
- Zolpidem EP Impurity D (CAS 836627-56-6)
- Azilsartan Impurity 112 (CAS CATO-C4X-1096112)
- Lopinavir EP Impurity D (CAS CATO-C4X-16824)
- 5-(1,3-Dioxolan-2-yl)-2-(3-methoxybenzoyl)thiophene (CAS 898773-11-0)
- 4-Aminoquinoline-7-carbonitrile (CAS 1253790-96-3)
- 2-Ethyl-4-methyl-6-(phenylamino)quinazoline-5,8-dione (CAS 61416-90-8)
- 3-(Chloromethyl)-5-methylimidazo[1,2-a]pyridine (CAS 1027229-57-7)
- 7-Phenyl-2,3-dihydro-1H-indole (CAS 92199-07-0)
- 3-{[4-(benzyloxy)phenyl]sulfamoyl}benzoic acid (CAS 380193-68-0)
- Fragment-[7-31]-Liraglutide (CAS CATO-C4X-199239)
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