Ramipril EP Impurity E CAS 87269-97-4
| CAS No. | 87269-97-4 |
| Molecular Formula | C21H28N2O5 |
| Molecular Weight | 388.46 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
CATO supplies Ramipril EP Impurity E (CAS 87269-97-4), a pharmacopoeial impurity reference standard (molecular formula C21H28N2O5, MW 388.46 g/mol) used for the identification and quantification of trace impurities in APIs.
The molecular framework of Ramipril EP Impurity E (C21H28N2O5) is characterized by a flavonoid core, an amide group, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C21H28N2O5 |
| Molecular Weight | 388.46 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | >45% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1981 |
| Nitrogen Atoms | 2 |
Related Ramipril Standards
- Ramipril EP Impurity D (CAS 108731-95-9)
- Ramipril EP Impurity A (CAS 108313-11-7)
- Ramipril EP Impurity K (CAS 108736-10-3)
- Ramipril EP Impurity L (CAS 1309040-96-7)
- Ramipril EP Impurity L(mixture) (CAS CATO-C4X-174412)
- Ramipril Impurity 1 (CAS CATO-C4X-17441)
- Ramipril (CAS 87333-19-5)
- Ramipril Impurity 27 (CAS 753405-33-3)
Recommended Standards
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- Insulin Degludec Impurity 2 (CAS CATO-C4X-21572)
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- N-Nitroso Cloxacillin Impurity 33 (CAS CATO-C4X-159733)
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- N1-Isopropyl-N1-(3-nitrobenzyl)ethane-1,2-diamine (CAS 1353955-35-7)
- (1-((2-(Trimethylsilyl)ethoxy)methyl)-1H-imidazol-4-yl)boronic acid (CAS 1682660-96-3)
- Semaglutide impurity 70 (CAS CATO-C4X-222670)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com