Avanafil Impurity 87 CAS 874482-97-0
| CAS No. | 874482-97-0 |
| Molecular Formula | C8H10ClNO |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a process- or degradation-related impurity, Avanafil Impurity 87 (CAS 874482-97-0, C8H10ClNOHCl) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Structurally, Avanafil Impurity 87 (C8H10ClNOHCl) contains an amide group, a hydroxyl group, an ether linkage, chlorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 3.0, corresponding to approximately 3 ring(s) or double-bond equivalent(s). With a molecular weight of 208.08 g/mol, it falls into the medium-molecular-weight range. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C8H10ClNO HCl |
| Molecular Weight | 208.08 g/mol |
| Appearance | White to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 95% |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 3.0 |
| UV Absorption | UV-absorbing |
| CAS Registry Year (est.) | 1987 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
Related Avanafil Standards
- Avanafil Impurity 77 (CAS 1201936-61-9)
- Avanafil Impurity 160 (CAS 1202002-16-1)
- Avanafil Impurity 3 (CAS 1364671-52-2)
- Avanafil Impurity 2 (CAS 1364671-62-4)
- Avanafil Impurity 110 (CAS 1368440-33-8)
- Avanafil Impurity 4 (CAS 1452128-53-8)
- Avanafil Impurity 133 (CAS 1508194-63-5)
- Avanafil Impurity 46 (CAS 1624833-89-1)
Recommended Standards
- Diltiazem Impurity 16 (CAS 3036581-85-5)
- Liraglutide Impurity 31 (CAS CATO-C4X-199231)
- Creatine impurity 18 (CAS CATO-C4X-120918)
- (E)-2-(2-Methylstyryl)-4,5-dihydro-1H-imidazole oxalate (CAS 221225-04-3)
- 4-Methyl-6-(trichloromethyl)-1,3,5-triazin-2-amine (CAS 21227-47-4)
- 1-{1-[(tert-butoxy)carbonyl]piperidin-4-yl}-5-methyl-1H-1,2,3-triazole-4-carboxylic acid (CAS 1240527-75-6)
- 2-(4-Bromophenyl)-1,1,1-trifluoropropan-2-yl methanesulfonate (CAS 1225380-04-0)
- 1-tert-Butyl 4-ethyl 6-methyl-5-oxoazepane-1,4-dicarboxylate (CAS 884487-29-0)
- Pt-tetraphenyltetrabenzoporphyrin (CAS 166174-05-6)
- Semaglutide impurity 67 (CAS CATO-C4X-222667)
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