Terbinafine EP Impurity D HCl CAS 877265-33-3
| CAS No. | 877265-33-3 |
| Molecular Formula | C22H27N |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
Terbinafine EP Impurity D HCl (CAS 877265-33-3) is a certified pharmaceutical impurity reference standard with the molecular formula C22H27NHCl and a molecular weight of 341.92 g/mol.
Terbinafine EP Impurity D HCl (C22H27NHCl) contains a nitrogen-containing heterocyclic scaffold, a nitrile group, chlorine substitution. Halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C22H27N HCl |
| Molecular Weight | 341.92 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1987 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
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Recommended Standards
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- Eldecalcitol Impurity 60 (CAS 66251-18-1)
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- 1-Isopropyl-4-(phenylsulfonyl)-1,2,3,4-tetrahydroquinoxaline (CAS 6344-74-7)
- Tert-butyl (S)-4-(3-bromophenyl)-1,2,3-oxathiazolidine-3-carboxylate 2,2-dioxide (CAS 1379546-88-9)
- Semaglutide impurity 203 (CAS CATO-C4X-2226203)
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