Famotidine EP Impurity H Dihydrochloride CAS 88046-01-9
| CAS No. | 88046-01-9 |
| Molecular Formula | C6H10N6S2 |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Famotidine EP Impurity H Dihydrochloride is closely related to a nitrile group, sulfur-containing functionality, chlorine substitution, an aromatic ring system in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
Famotidine EP Impurity H Dihydrochloride (CAS 88046-01-9) is a certified pharmaceutical impurity reference standard with the molecular formula C6H10N6S2HCl and a molecular weight of 266.77 g/mol.
Famotidine EP Impurity H Dihydrochloride (C6H10N6S2HCl) contains a nitrile group, sulfur-containing functionality, chlorine substitution, an aromatic ring system. Halogen substitution raises its density and boiling point; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C6H10N6S2 2*HCl |
| Molecular Weight | 266.77 g/mol |
| Purity | >90% |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1982 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 6 |
| Sulfur Atoms | 2 |
Related Famotidine Standards
- Famotidine impurity HCl, >98% (CAS 100599-91-5)
- Famotidine EP Impurity I (CAS 1020719-36-1)
- Famotidine EP Impurity C (CAS 106433-44-7)
- Famotidine Impurity 23 (CAS 106649-95-0)
- Famotidine EP Impurity H (CAS 106649-96-1)
- Famotidine EP Impurity F (CAS 107880-74-0)
- Famotidine EP Impurity B Dimaleate (CAS 109467-08-5)
- Famotidine impurity 01 (CAS 1185040-73-6)
Recommended Standards
- Roflumilast Impurity 3 (CAS 1391052-24-6)
- Cefprozil Impurity 33 (CAS CATO-C4X-149233)
- N-Nitroso Amoxicillin Impurity K (CAS CATO-C4X-114880)
- Potassium (2,4-dimethoxypyrimidin-5-yl)trifluoroborate (CAS 1111732-97-8)
- 3-Aminocrotonitrile (CAS 1118-61-2)
- N-(sec-butyl)quinolin-8-amine (CAS 343953-25-3)
- 2,2'-(((5-Chloro-1H-benzo[d]imidazol-2-yl)methyl)azanediyl)diacetic acid (CAS 72998-94-8)
- 2-(2,2-Difluoroethoxy)-4,6-dimethoxypyrimidine (CAS 552882-12-9)
- 3-(3-Cyano-4-fluorophenyl)-2-methyl-1-propene (CAS 951888-69-0)
- Semaglutide impurity 88 (CAS CATO-C4X-222688)
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