Cholesterol Impurity 29 CAS 881024-99-3
| CAS No. | 881024-99-3 |
| Molecular Formula | C27H44O |
| Molecular Weight | 384.64 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Cholesterol Impurity 29.
As a process- or degradation-related impurity, Cholesterol Impurity 29 (CAS 881024-99-3, C27H44O) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Cholesterol Impurity 29 (C27H44O) contains a steroid core, a hydroxyl group, an ether linkage. Its high carbon-to-hydrogen ratio confers good lipid solubility; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Cholesterol Impurity 29 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C27H44O |
| Molecular Weight | 384.64 g/mol |
| Appearance | Off-white to pale yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1987 |
Related Cholesterol Standards
- Cholesterol EP Impurity C (CAS 651-54-7)
- Cholesterol Impurity 17 (CAS 14214-69-8)
- Cholesterol Impurity 30 (CAS 17608-47-8)
- Cholesterol Impurity 31 (CAS 117556-83-9)
- Cholesterol probe for Smoothened (CAS CATO-C3D-262450)
- Cholesterol Impurity 25 (CAS CATO-C4X-196725)
- Cholesterol Impurity 36 (CAS 7199-91-9)
- Cholesterol EP Impurity A (CAS 80-99-9)
Recommended Standards
- 8-Dehydrocholesterol (CAS 70741-38-7)
- Desmosterol (CAS 313-04-2)
- Precalciferol (Previtamin D3) (CAS 1173-13-3)
- 3-Keto Cholesterol (CAS 601-54-7)
- Betamethasone EP Impurity G (CAS 85700-75-0)
- Faropenem Impurity 24 (CAS CATO-C4X-128924)
- Bendamustine Impurity 26 (CAS 2489521-68-6)
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