Apixaban Impurity 84 CAS 881386-01-2
| CAS No. | 881386-01-2 |
| Molecular Formula | C11H10Cl2N2O3 |
| Molecular Weight | 289.11 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Apixaban Impurity 84 (CAS 881386-01-2) is a certified pharmaceutical impurity reference standard with the molecular formula C11H10Cl2N2O3 and a molecular weight of 289.11 g/mol.
Apixaban Impurity 84 (C11H10Cl2N2O3) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C11H10Cl2N2O3 |
| Molecular Weight | 289.11 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1987 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
Related Apixaban Standards
- Apixaban Impurity 130 (CAS CATO-C4X-1088130)
- Apixaban Impurity 115 (CAS CATO-C4X-1088115)
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Recommended Standards
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- Viloxazine Impurity 7 (CAS CATO-C4X-31317)
- Ganciclovir Impurity C08 (CAS 84245-12-5)
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- Arotinolol Impurity 11 (CAS 68257-90-9)
- 1-Isobutyl-1h-benzo[d]imidazole-5-carboxylic acid (CAS 1036468-82-2)
- n-(1-Benzylpiperidin-4-yl)-n-(1-phenylcyclopentyl)formamide (CAS 440087-77-4)
- Bicyclo[2.2.2]octa-2,5-diene-2-carboxylic Acid (CAS 102589-30-0)
- 2-(Chloromethyl)-4-isopropylpyridine (CAS 1211580-09-4)
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