2-((1-(3-Chloro-4-methylphenyl)-2,5-dioxopyrrolidin-3-yl)thio)nicotinic acid CAS 881483-69-8
| CAS No. | 881483-69-8 |
| Molecular Formula | C17H13ClN2O4S |
| Molecular Weight | 376.81 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of 2-((1-(3-Chloro-4-methylphenyl)-2,5-dioxopyrrolidin-3-yl)thio)nicotinic acid is closely related to a flavonoid core, an amide group, a sulfone group, a hydroxyl group, an ether linkage, chlorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
2-((1-(3-Chloro-4-methylphenyl)-2,5-dioxopyrrolidin-3-yl)thio)nicotinic acid (CAS 881483-69-8) is a high-purity analytical reference standard with the molecular formula C17H13ClN2O4S and a molecular weight of 376.81 g/mol.
The molecular framework of 2-((1-(3-Chloro-4-methylphenyl)-2,5-dioxopyrrolidin-3-yl)thio)nicotinic acid (C17H13ClN2O4S) is characterized by a flavonoid core, an amide group, a sulfone group, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
CATO manufactures 2-((1-(3-Chloro-4-methylphenyl)-2,5-dioxopyrrolidin-3-yl)thio)nicotinic acid under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C17H13ClN2O4S |
| Molecular Weight | 376.81 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1987 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
| Sulfur Atoms | 1 |
Related Chloro Standards
- 4-Chloro-N-[(naphthalen-1-yl)methyl]-2-nitrobenzene-1-sulfonamide (CAS 1022360-31-1)
- 2-Chloro-4-fluoro-N-(4-(2-morpholino-2-oxoethyl)phenyl)benzamide (CAS 1070960-22-3)
- 2-Chloro-6-fluoro-N-(2-methoxyphenyl)-N-((2-oxopyrrolidin-1-yl)methyl)benzamide (CAS 852132-09-3)
- Ethyl 1-[(4-chloro-3-nitrophenyl)sulfonyl]-4-piperidinecarboxylate (CAS 291292-03-0)
- 5-Chloro-N2-(4-fluorobenzyl)-N4-(5-isopropoxy-1H-pyrazol-3-yl)pyrimidine-2,4-diamine (CAS 1447605-97-1)
- 4-Chloro-7-(3-morpholinopropoxy)-6-nitroquinoline-3-carbonitrile (CAS 919482-04-5)
- 5-Chloro-1,3-dimethyl-N-(2-morpholino-2-oxo-1-phenylethyl)-1H-pyrazole-4-carboxamide (CAS 1030609-39-2)
- 4-((2-Chloro-6-fluorobenzylidene)amino)-3-(3-ethoxyphenyl)-1H-1,2,4-triazole-5(4H)-thione (CAS 497921-66-1)
Recommended Standards
- (5Z)-5-({4-[(6-chloropyridin-3-yl)methoxy]-3-methoxyphenyl}methylidene)-1,3-thiazolidine-2,4-dione (CAS 860783-86-4)
- 2-[(4-Chlorophenyl)sulfanyl]-N-(2,4-difluorophenyl)pyridine-3-carboxamide (CAS 400078-98-0)
- Copper dichlorobis(2,4,6-trimethylpyridine)- (CAS 14430-03-6)
- 6-(2-(4-Chlorophenylsulfonamido)-2-oxoacetamido)hexanoic acid (CAS 701210-22-2)
- 3-Chloro-4-(1h-imidazol-1-yl)aniline (CAS 869942-76-7)
- 4-Chloro-N-(3-fluoro-4-methylphenyl)benzamide (CAS 328026-95-5)
- 8-(2,4-Dihydroxyphenyl)-4-hydroxy-2-methyl-2-(4-methylpent-3-en-1-yl)-7,8-dihydro-2H,6H-pyrano[3,2-g]chromen-6-one (CAS 123702-94-3)
- 3,5-Dibutyl-4H-1,2,4-triazol-4-amine (CAS 62695-58-3)
- N-Methyl-N-phenylbenzamide (CAS 1934-92-5)
- 3,5-Difluoro-2-nitrophenacyl chloride (CAS 1803788-00-2)
- 4-(2-(4-(3,5-Dichlorophenyl)-1-Piperazinyl)Ethyl)-5-(4-Fluorophenyl)-1 ,3-Dioxol-2-One hydrochloride (CAS 71923-04-1)
- 7-Bromo-2-(tert-butyl)naphthalen-1-ol (CAS 1257832-92-0)
- 3-Bromo-5-(trifluoromethoxy)pyridin-2-amine (CAS 1361693-01-7)
- Semaglutide impurity 26 (CAS CATO-C4X-222626)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com