Vonoprazan Impurity 130 CAS 881674-06-2
| CAS No. | 881674-06-2 |
| Molecular Formula | C13H12FNO2 |
| Molecular Weight | 233.24 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The molecular framework of Vonoprazan Impurity 130 (C13H12FNO2) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Vonoprazan Impurity 130 (CAS 881674-06-2) is a certified pharmaceutical impurity reference standard with the molecular formula C13H12FNO2 and a molecular weight of 233.24 g/mol.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Vonoprazan Impurity 130 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C13H12FNO2 |
| Molecular Weight | 233.24 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1987 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
Related Vonoprazan Standards
- Vonoprazan Impurity 197 (CAS CATO-C4X-1020197)
- Vonoprazan Impurity 293 (CAS 3033403-71-0)
- Vonoprazan Impurity 298 (CAS 103860-56-6)
- Vonoprazan Impurity 136 (CAS CATO-C4X-1020136)
- Vonoprazan Impurity 271 (CAS CATO-C4X-1020271)
- Vonoprazan Impurity 49 (CAS CATO-C4X-1020249)
- Vonoprazan Impurity 121 (CAS 13069-92-4)
- Vonoprazan Impurity 223 (CAS 13069-04-0)
Recommended Standards
- 3-Fluoro-4-(2-methoxyphenoxy)phenylamine 4000AF 946663-94-1 C13H12FNO2 (CAS 946663-94-1)
- 5-(5-Formylpyridin-2-yl)thiophene-2-carboxylic acid 844495-45-0 (CAS 844495-45-0)
- 3-[5-(4-Fluoro-phenyl)-1H-pyrrol-2-yl]-propionic acid 3313AE 432496-81-6 C13H12FNO2 (CAS 432496-81-6)
- Isavuconazole Impurity 106 (CAS 150803-17-1)
- Biapenem Impurity 23 (CAS CATO-C4X-227323)
- Aprocitentan impurity 2 (CAS CATO-C4X-33552)
- Gatifloxacin Impurity 3 (CAS 616205-76-6)
- Phenyl-prop-2-ynyl-amine hydrochloride (CAS 18158-70-8)
- 1-Methyl-3-(oxan-4-yl)-1H-pyrazole-4-carbaldehyde (CAS 1782032-82-9)
- N-(5-chloro-2-methylphenyl)-1-(3,4-dimethylphenyl)-5-methyl-1H-1,2,3-triazole-4-carboxamide (CAS 866847-95-2)
- 3-(1-Benzyl-3-phenyl-1H-pyrazol-4-yl)acrylic acid (CAS 1006494-12-7)
- Methyl 6-bromo-4,5-dimethoxypicolinate (CAS 214123-12-3)
- 3-(4-(Dimethylamino)phenyl)-4-hydroxycyclobut-3-ene-1,2-dione (CAS 107885-39-2)
- Peptide-GMF (CAS CATO-CPTD788469)
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