3-[1,1'-biphenyl]-4-yl-N-(4-chlorobenzyl)acrylamide CAS 882083-87-6
| CAS No. | 882083-87-6 |
| Molecular Formula | C22H18ClNO |
| Molecular Weight | 347.84 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
3-[1,1'-biphenyl]-4-yl-N-(4-chlorobenzyl)acrylamide (CAS 882083-87-6) is a high-purity analytical reference standard with the molecular formula C22H18ClNO and a molecular weight of 347.84 g/mol.
The molecular framework of 3-[1,1'-biphenyl]-4-yl-N-(4-chlorobenzyl)acrylamide (C22H18ClNO) is characterized by a steroid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C22H18ClNO |
| Molecular Weight | 347.84 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 14.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1987 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
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Recommended Standards
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- 6,8-Dihydro-5H-imidazo[2,1-c][1,4]thiazine-2-carbaldehyde (CAS 623564-35-2)
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