trans-2-(difluoromethyl)cyclopropanecarboxylic acid CAS 883443-58-1
| CAS No. | 883443-58-1 |
| Molecular Formula | C5H6F2O2 |
| Molecular Weight | 136.10 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
trans-2-(difluoromethyl)cyclopropanecarboxylic acid (CAS 883443-58-1), molecular formula C5H6F2O2 and molecular weight 136.10 g/mol, is a CATO reference standard with documented purity and traceability.
Owing to a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine substitution, trans-2-(difluoromethyl)cyclopropanecarboxylic acid is typically white to off-white liquid. Its solid-state physicochemical attributes — including a molecular weight of 136.10 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
As a certified reference material (CRM), trans-2-(difluoromethyl)cyclopropanecarboxylic acid meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C5H6F2O2 |
| Molecular Weight | 136.10 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 2.0 |
| CAS Registry Year (est.) | 1987 |
| Halogen Content | F-containing |
Related trans Standards
- 1-(Difluoromethyl)cyclopropanecarboxylic Acid (CAS 1314397-71-1)
- 2-(difluoromethyl)cyclopropanecarboxylic acid (CAS 1314960-20-7)
- cis-2-(difluoromethyl)cyclopropanecarboxylic acid (CAS 2278284-80-1)
- 2-(Difluoromethyl)piperazine (CAS 111759-98-9)
- (3-(Difluoromethyl)azetidin-3-yl)methanamine (CAS 1779935-18-0)
- (2-(Difluoromethyl)cyclobutyl)methanol (CAS 1780163-99-6)
- [1-(difluoromethyl)cyclobutyl]methanol (CAS 1780499-30-0)
- 4-(Difluoromethyl)tetrahydro-2H-pyran (CAS 1820618-46-9)
Recommended Standards
- Threonic acid (CAS 3909-12-4)
- 2,3,4-Trihydroxybutanoicacid (CAS 10191-35-2)
- rel-2,2-Difluoro-3-methylcyclopropane-1-carboxylic acid (CAS 2247657-28-7)
- 3,6-Dioxocyclohexa-1,4-diene-1-carbaldehyde (CAS 26172-03-2)
- (4-Methylpyridin-3-yl)boronic acid hydrochloride (CAS 1428882-29-4)
- 2-Amino-N-cyclohexyl-3-phenylpropanamide (CAS 92698-80-1)
- Isopropyl 1-methyl-1H-pyrazole-4-sulfonate (CAS CATO-C3D-2473)
- (R)-2-(2,5-Dimethoxyphenyl)piperazine (CAS 1212929-05-9)
- 1-(4-BRomo-2-chlorophenyl)guanidine (CAS 1249016-90-7)
- LCZ-696 Impurity 84 (CAS 5717-37-3)
- 1-(2,6-Difluorophenyl)-3-(4-(pyrrolidin-1-yl)but-2-yn-1-yl)urea (CAS 1396750-10-9)
- Ethyl 2-ethyl-5-nitropyridine-3-carboxylate (CAS 923145-41-9)
- Orforglipron impurity 23 (CAS 2212021-40-2)
- Tirzepatide Impurity 25 X TFA Salt (CAS CATO-C4X-324025)
Why CATO?
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