cis-2-(difluoromethyl)cyclopropanecarboxylic acid CAS 2278284-80-1
| CAS No. | 2278284-80-1 |
| Molecular Formula | C5H6F2O2 |
| Molecular Weight | 136.10 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
cis-2-(difluoromethyl)cyclopropanecarboxylic acid (CAS 2278284-80-1) is a high-purity analytical reference standard with the molecular formula C5H6F2O2 and a molecular weight of 136.10 g/mol.
The molecular framework of cis-2-(difluoromethyl)cyclopropanecarboxylic acid (C5H6F2O2) is characterized by a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by the polarity and ionization state of its functional groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
As a certified reference material (CRM), cis-2-(difluoromethyl)cyclopropanecarboxylic acid meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C5H6F2O2 |
| Molecular Weight | 136.10 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 2.0 |
| CAS Registry Year (est.) | 1998 |
| Halogen Content | F-containing |
Related cis Standards
- 1-(Difluoromethyl)cyclopropanecarboxylic Acid (CAS 1314397-71-1)
- 2-(difluoromethyl)cyclopropanecarboxylic acid (CAS 1314960-20-7)
- trans-2-(difluoromethyl)cyclopropanecarboxylic acid (CAS 883443-58-1)
- 2-(Difluoromethyl)piperazine (CAS 111759-98-9)
- (3-(Difluoromethyl)azetidin-3-yl)methanamine (CAS 1779935-18-0)
- (2-(Difluoromethyl)cyclobutyl)methanol (CAS 1780163-99-6)
- [1-(difluoromethyl)cyclobutyl]methanol (CAS 1780499-30-0)
- 4-(Difluoromethyl)tetrahydro-2H-pyran (CAS 1820618-46-9)
Recommended Standards
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- rel-2,2-Difluoro-3-methylcyclopropane-1-carboxylic acid (CAS 2247657-28-7)
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- Semaglutide impurity 86 (CAS CATO-C4X-152686)
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