Vonoprazan Impurity 198 CAS 887577-48-2
| CAS No. | 887577-48-2 |
| Molecular Formula | C5H5NO7S2 |
| Molecular Weight | 255.23 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Vonoprazan Impurity 198 (C5H5NO7S2) contains a carbohydrate-derived structure, an amide group, a sulfone group. It is notably hygroscopic, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
As a process- or degradation-related impurity, Vonoprazan Impurity 198 (CAS 887577-48-2, C5H5NO7S2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C5H5NO7S2 |
| Molecular Weight | 255.23 g/mol |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO, water |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| CAS Registry Year (est.) | 1987 |
| Nitrogen Atoms | 1 |
| Sulfur Atoms | 2 |
Related Vonoprazan Standards
- Vonoprazan Impurity 167 (CAS CATO-C4X-1020167)
- Vonoprazan Impurity 243 (CAS CATO-C4X-1020243)
- Vonoprazan Fumarate Impurity 86 (CAS CATO-C4X-102086)
- Vonoprazan Impurity 132 (CAS 881673-98-9)
- Vonoprazan Impurity 48 (CAS CATO-C4X-1020248)
- Vonoprazan Impurity 82 (CAS 106058-86-0)
- Vonoprazan Impurity 131 (CAS 881674-01-7)
- Vonoprazan Impurity 251 (CAS CATO-C4X-1020251)
Recommended Standards
- Aciclovir Impurity Q (CAS CATO-C4X-101038)
- Ganciclovir EP Impurity E (CAS 86357-09-7)
- Aciclovir Impurity 29 (CAS CATO-C4X-101029)
- Ganciclovir EP Impurity H (CAS 84222-50-4)
- Capivasertib Impurity 42 (CAS CATO-C4X-331242)
- Tenofovir alafenamide Impurity 17 (CAS 382140-25-2(Free Base))
- Fluticasone Impurity 59 (CAS CATO-C4X-165059)
- tert-butyl(3,5-difluorophenoxy)dimethylsilane (CAS 917827-99-7)
- 3-(Isopentyloxy)benzenethiol (CAS 1378822-08-2)
- N-(2,6-Difluorophenyl)-3-methylbenzamide (CAS 838852-23-6)
- Isobutyl pyrimidin-2-ylcarbamate (CAS 824933-16-6)
- (S)-1-(5-Fluoropyrimidin-2-yl)ethanamine hydrochloride(1:x) (CAS 1075756-60-3)
- Fluralaner Impurity 10 (CAS 864731-37-3)
- Liraglutide(13-31)TFA Salt (CAS CATO-C4X-19929)
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