Rivaroxaban Impurity N1 CAS 88777-57-5
| CAS No. | 88777-57-5 |
| Molecular Formula | C7H8ClNOS |
| Molecular Weight | 189.66 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 189.66 g/mol gives Rivaroxaban Impurity N1 distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
As a process- or degradation-related impurity, Rivaroxaban Impurity N1 (CAS 88777-57-5, C7H8ClNOS) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Structurally, Rivaroxaban Impurity N1 (C7H8ClNOS) contains an amide group, sulfur-containing functionality, a hydroxyl group, an ether linkage, chlorine substitution, an aromatic ring system. The molecule exhibits a degree of unsaturation (DBE) of 4.0, corresponding to approximately 4 ring(s) or double-bond equivalent(s). With a molecular weight of 189.66 g/mol, it falls into the medium-molecular-weight range. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Rivaroxaban Impurity N1 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C7H8ClNOS |
| Molecular Weight | 189.66 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1982 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
| Sulfur Atoms | 1 |
Related Rivaroxaban Standards
- Rivaroxaban Impurity 41 (CAS 142910-02-9)
- Rivaroxaban Impurity 87 (CAS 96800-35-0)
- Rivaroxaban impurity 193 (CAS CATO-C4X-1090193)
- Rivaroxaban Impurity 32 (CAS 438056-69-0)
- Rivaroxaban Impurity 47 (CAS 1082588-73-5)
- Rivaroxaban Impurity 57 (CAS 1082495-22-4)
- Rivaroxaban Impurity 83 (CAS 1456733-00-8)
- Rivaroxaban Impurity 96 (CAS 1007650-38-5)
Recommended Standards
- 5-Dichloro-2-methoxy-4-(methylthio)pyridine (CAS 474824-69-6)
- Sulfoximine, S-(2-chlorophenyl)-S-methyl- (CAS 92523-34-7)
- 4-Isopropylthiazole-2-carbonyl chloride (CAS 923289-59-2)
- 2-(5-Chloro-1-methyl-1h-imidazol-2-yl)ethanethioamide (CAS 1211349-15-3)
- Ibuprofen Impurity 159 (CAS 1957156-46-5)
- Orforglipron Impurity 104 (CAS CATO-C4X-3234104)
- Tenofovir disoproxil Impurity 86 (CAS 31618-90-3)
- Finerenone Impurity 36 (CAS 2087452-81-9)
- Benzo[d][1,3]dioxol-5-yl acetate (CAS 326-58-9)
- 3-(3-Chlorophenyl)-1-(3,5-difluorophenyl)propan-1-one (CAS 898787-46-7)
- Tris(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)amine (CAS 267221-90-9)
- 2-(Dimethylamino)-N-(3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)ethane-1-sulfonamide (CAS 756521-01-4)
- Tiamulin impurity 10 (CAS CATO-C4X-221010)
- Semaglutide impurity 31 (CAS CATO-C4X-222631)
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