Tenofovir disoproxil Impurity 86 CAS 31618-90-3
| CAS No. | 31618-90-3 |
| Molecular Formula | C12H19O6PS |
| Molecular Weight | 322.31 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Tenofovir disoproxil Impurity 86 (CAS 31618-90-3) is a certified pharmaceutical impurity reference standard with the molecular formula C12H19O6PS and a molecular weight of 322.31 g/mol.
The molecular framework of Tenofovir disoproxil Impurity 86 (C12H19O6PS) is characterized by a sulfone group, a phosphate ester group, a carboxylic acid group, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by the polarity and ionization state of its functional groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C12H19O6PS |
| Molecular Weight | 322.31 g/mol |
| Purity | >95% |
| Storage | Store in a cool place (≤25°C), keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 3.5 |
| UV Absorption | UV-absorbing |
| CAS Registry Year (est.) | 1966 |
| Sulfur Atoms | 1 |
Related Tenofovir Standards
- Tenofovir Impurity 64 (CAS CATO-C4X-107664)
- Tenofovir Impurity 69 (CAS 1878175-74-6)
- Tenofovir disoproxil Impurity 98 (CAS 1255525-18-8)
- Tenofovir alafenamide Impurity 12 (CAS 1796545-19-1)
- Tenofovir disoproxil Impurity 124 (CAS CATO-C4X-1076124)
- Tenofovir Disoproxil Impurity 46 (CAS CATO-C4X-107646)
- Tenofovir Impurity 51 (CAS 60682-95-3)
- Tenofovir disoproxil Impurity 122 (CAS 1217630-57-3)
Recommended Standards
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- Pumitepa (CAS 42061-52-9)
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- Mebenil (CAS 7055-03-0)
- 4-(2-(4-Chlorobenzoyl)hydrazinyl)-4-oxobutanoic acid (CAS 215121-50-9)
- 3-Methyloct-7-en-2-one (CAS 3664-61-7)
- 5-Amino-6-bromonicotinic acid (CAS 1292765-17-3)
- Semaglutide Impurity 146 (CAS 2645421-68-5)
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